Justicidin F

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462019

CAS#: 30403-00-0

Description: Justicidin F is a compound of M. angustifolia, may be a novel agent for AD treatment.

Chemical Structure

Justicidin F
CAS# 30403-00-0

Theoretical Analysis

MedKoo Cat#: 462019
Name: Justicidin F
CAS#: 30403-00-0
Chemical Formula: C21H14O7
Exact Mass: 378.074
Molecular Weight: 378.336
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Justicidin F; Taiwanin e methyl ether

IUPAC/Chemical Name: 5-(benzo[d][1,3]dioxol-5-yl)-9-methoxyfuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one


InChi Code: InChI=1S/C21H14O7/c1-23-20-12-6-17-16(27-9-28-17)5-11(12)18(19-13(20)7-24-21(19)22)10-2-3-14-15(4-10)26-8-25-14/h2-6H,7-9H2,1H3

SMILES Code: COC(C1=CC2=C(OCO2)C=C1C(C3=CC4=C(OCO4)C=C3)=C56)=C5COC6=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 378.336 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Justicidin B: A Promising Bioactive Lignan Shiva Hemmati, Hassan Seradj Molecules. 2016 Jul; 21(7): 820. Published online 2016 Jun 23. doi: 10.3390/molecules21070820 PMCID: PMC6272961

2: Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein Yoon Sun Chun, Oh-Hoon Kwon, Hyun Geun Oh, Yoon Young Cho, Hyun Ok Yang, Sungkwon Chung Biomol Ther (Seoul) 2019 May; 27(3): 276–282. Published online 2018 Oct 11. doi: 10.4062/biomolther.2018.112 PMCID: PMC6513189

3: Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness Joshua C. Snyder, Lauren K. Rochelle, Caroline Ray, Thomas F. Pack, Cheryl B. Bock, Veronica Lubkov, H. Kim Lyerly, Alan S. Waggoner, Larry S. Barak, Marc G. Caron J Biol Chem. 2017 Apr 28; 292(17): 7208–7222.
Published online 2017 Mar 8. doi: 10.1074/jbc.M116.756635 PMCID: PMC5409487

4: Flavonoids and Ellagitannins Characterization, Antioxidant and Cytotoxic Activities of Phyllanthus acuminatus Vahl Mirtha Navarro, Ileana Moreira, Elizabeth Arnaez, Silvia Quesada, Gabriela Azofeifa, Felipe Vargas, Diego Alvarado, Pei Chen Plants (Basel) 2017 Dec; 6(4): 62. Published online 2017 Dec 15. doi: 10.3390/plants6040062 PMCID: PMC5750638

5: 6′-Hydroxy Justicidin B Triggers a Critical Imbalance in Ca2+ Homeostasis and Mitochondrion-Dependent Cell Death in Human Leukemia K562 Cells Jiaoyang Luo, Jiaan Qin, Yanwei Fu, Shanshan Zhang, Xingguo Zhang, Meihua Yang Front Pharmacol. 2018; 9: 601. Published online 2018 Jun 6. doi: 10.3389/fphar.2018.00601 PMCID: PMC6008565

6: A Strategy for Preparative Separation of 10 Lignans from Justicia procumbens L. by High-Speed Counter Current Chromatography Jiaojiao Jiang, Hongjing Dong, Tao Wang, Ruixuan Zhao, Yan Mu, Yanling Geng, Zhenjia Zheng, Xiao Wang Molecules. 2017 Dec; 22(12): 2024. Published online 2017 Nov 23. doi: 10.3390/molecules22122024 PMCID: PMC6149811

7: Preparative Isolation and Purification of Lignans from Justicia procumbens Using High-Speed Counter-Current Chromatography in Stepwise Elution Mode Peijuan Zhou, Qijun Luo, Lijian Ding, Fang Fang, Ye Yuan, Juanjuan Chen, Jinrong Zhang, Haixiao Jin, Shan He Molecules. 2015 Apr; 20(4): 7048–7058. Published online 2015 Apr 20. doi: 10.3390/molecules20047048 PMCID: PMC6272366

8: Evaluation and Structure-Activity Relationship Analysis of a New Series of Arylnaphthalene lignans as Potential Anti-Tumor Agents Jiaoyang Luo, Yichen Hu, Weijun Kong, Meihua Yang PLoS One. 2014; 9(3): e93516. Published online 2014 Mar 27. doi: 10.1371/journal.pone.0093516 PMCID: PMC3968169

9: Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans Chien-Ming Wu, Shu-Chun Wu, Wan-Jung Chung, Hsien-Cheng Lin, Kun-Tze Chen, Yu-Chian Chen, Mei-Feng Hsu, Jwu-Maw Yang, Jih-Pyang Wang, Chun-Nan Lin Int J Mol Sci. 2007 Aug; 8(8): 830–841. Published online 2007 Aug 22. PMCID: PMC3715805

10: Anti-Inflammatory and Antinociceptive Studies of Hydroalcoholic Extract from the Leaves of Phyllanthus brasiliensis (Aubl.) Poir. and Isolation of 5-O-β-d-Glucopyranosyljusticidin B and Six Other Lignans Luziane da C. Borges, Raimundo Negrão-Neto, Sônia Pamplona, Luanna Fernandes, Mayra Barros, Enéas Fontes-Júnior, Cristiane Maia, Consuelo Y. Yoshioka e Silva, Milton Nascimento da Silva Molecules. 2018 Apr; 23(4): 941. Published online 2018 Apr 18. doi: 10.3390/molecules23040941 PMCID: PMC6017254