WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461983
CAS#: 19431-20-0
Description: 14-dehydro Zymostenol is a precursor to cholesterol. It increases the percentage of myelin basic protein-positive (MBP) oligodendrocytes formed from oligodendrocyte precursor cells.
MedKoo Cat#: 461983
Name: 14-dehydro Zymostenol
CAS#: 19431-20-0
Chemical Formula: C27H44O
Exact Mass: 384.3392
Molecular Weight: 384.648
Elemental Analysis: C, 84.31; H, 11.53; O, 4.16
Synonym: 14-dehydro Zymostenol; Cholesta-8,14-dien-3β-ol; Δ8,14-Cholestandienol
IUPAC/Chemical Name: (3β,5α)-cholesta-8,14-dien-3-ol
InChi Key: AWBZPJQUWZBRII-CXDHQSPESA-N
InChi Code: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h12,18-21,23,28H,6-11,13-17H2,1-5H3/t19-,20+,21+,23-,26+,27-/m1/s1
SMILES Code: C[C@H](CCCC(C)C)[C@@]1([H])CC=C([C@]1(C)CC2)C3=C2[C@]4(C)[C@](CC3)([H])C[C@@H](O)CC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 384.648 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Lutsky BN, Schroepfer GJ Jr. Studies on the enzymatic conversion of 5 alpha-cholesta-8, 14-dien-3 beta-ol to cholesterol. J Biol Chem. 1970 Dec 10;245(23):6449-55. PubMed PMID: 5484819.
2: Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. PubMed PMID: 30046109; PubMed Central PMCID: PMC6423962.
