WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593189
CAS#: 2421117-98-6
Description: BC-DXI-843 is AIMP2-DX2 inhibitor. It as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.
MedKoo Cat#: 593189
Name: BC-DXI-843
CAS#: 2421117-98-6
Chemical Formula: C28H26N4O4S2
Exact Mass: 546.1395
Molecular Weight: 546.66
Elemental Analysis: C, 61.52; H, 4.79; N, 10.25; O, 11.71; S, 11.73
Synonym: BCDXI843; BCDXI-843; BCDXI 843; BC-DXI-843; BC-DXI843; BC-DXI 843;
IUPAC/Chemical Name: (S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide
InChi Key: VLPGAOXBMXGNGM-VWLOTQADSA-N
InChi Code: InChI=1S/C28H26N4O4S2/c1-18-7-13-22(14-8-18)38(34,35)32-25(15-20-16-29-24-6-4-3-5-23(20)24)27(33)31-28-30-26(17-37-28)19-9-11-21(36-2)12-10-19/h3-14,16-17,25,29,32H,15H2,1-2H3,(H,30,31,33)/t25-/m0/s1
SMILES Code: O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)[C@@H](NS(=O)(C3=CC=C(C)C=C3)=O)CC4=CNC5=C4C=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 546.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Aneesh Sivaraman, Dae Gyu Kim, Deepak Bhattarai, Minkyoung Kim, Hwa Young Lee, Semi Lim, Jiwon Kong, Ja-il GooSeunghwan Shim, Seungbeom Lee, Young-Ger Suh,Yongseok Choi, Sunghoon Kim, Kyeong Lee. Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J. Med. Chem. 2020. doi: 10.1021/acs.jmedchem.9b01961.
