CIN16645 | CAS#1799316-64-5

CIN16645
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555767

CAS#: 1799316-64-5 (free base)

Description: CIN16645, also known as LP-01 lipid, is an ionizable lipid, IT is useful in lipid nanopparticle formulation for DNA and RNA vaccine delivery and Gene editing. CIN16645 was first reported in Novartis patent WO 2015095340A1. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming)..

Chemical Structure

CIN16645

CAS# 1799316-64-5 (free base)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555767
Name: CIN16645
CAS#: 1799316-64-5 (free base)
Chemical Formula: C50H93NO9
Exact Mass: 851.69
Molecular Weight: 852.292
Elemental Analysis: C, 70.46; H, 11.00; N, 1.64; O, 16.89

Price and Availability

Size	Price	Availability
5mg	USD 150	Ready to ship
10mg	USD 250	Ready to ship
25mg	USD 450	Ready to ship
50mg	USD 750	Ready to ship
100mg	USD 1250	Ready to ship
200mg	USD 1950	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: CIN16645 HCl 1799316-64-5 (free base)

Synonym: CIN-16645; CIN 16645; CIN16645; LP-01 lipid;

IUPAC/Chemical Name: 3-((4,4-bis(octyloxy)butanoyl)oxy)-2-((((3-(diethylamino)propoxy)carbonyl)oxy)methyl)propyl (9Z,12Z)-octadeca-9,12-dienoate

InChi Key: CHTXXFZHKGGQGX-IFLFXUNCSA-N

InChi Code: InChI=1S/C50H93NO9/c1-6-11-14-17-20-21-22-23-24-25-26-27-28-29-32-36-47(52)58-43-46(45-60-50(54)57-42-35-39-51(9-4)10-5)44-59-48(53)37-38-49(55-40-33-30-18-15-12-7-2)56-41-34-31-19-16-13-8-3/h20-21,23-24,46,49H,6-19,22,25-45H2,1-5H3/b21-20-,24-23-

SMILES Code: CCCCC/C=C\C/C=C\CCCCCCCC(OCC(COC(OCCCN(CC)CC)=O)COC(CCC(OCCCCCCCC)OCCCCCCCC)=O)=O

Appearance: Oily Liquid (Lipid)

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#YXM200521
View CoA: current batch, Lot#Y22X09M12

QC Data:

View QC data: current batch, Lot#YXM200521
View QC data: current batch, Lot#Y22X09M12

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	CIN-16645 is a cationic lipid and is useful in the delivery of biologically active agents to cells and tissues.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 852.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1. Brito, Luis; Chen, Delai; Gamber, Gabriel Grant; Geall, Andrew; Love, Kevin; Zabawa, Thomas; Zecri, Frederic (Novartis AG, Switz.). WO2015095340A1

2. Morrissey, David V.; Patel, Mihir Chandrakant; Finn, Jonathan D.; Smith, Amy Madison Rhoden; Shaw, Lucinda J.; Dombrowski, Christian; Shah, Ruchi Rudraprasad (Assignee: Intellia Therapeutics, Inc., USA), Lipid nanoparticle formulations for CRISPR/Cas components, WO 2017173054.

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CIN16645 featured