EC-5026
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555766

CAS#: 1809885-32-2

Description: EC5026, also known as BPN-19186, is a first-in-class, potent and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of polyunsaturated fatty acids (EpFA), which are natural mediators that reduce pain, resolve inflammation, and maintain normal blood pressure. EC5026 is a slow-tight binding transition-state mimic that inhibits the soluble epoxide hydrolase (sEH) at picomolar concentrations.

Chemical Structure

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EC-5026
CAS# 1809885-32-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555766
Name: EC-5026
CAS#: 1809885-32-2
Chemical Formula: C18H23F4N3O3
Exact Mass: 405.17
Molecular Weight: 405.394
Elemental Analysis: C, 53.33; H, 5.72; F, 18.75; N, 10.37; O, 11.84

Price and Availability

Size Price Availability Quantity
5mg USD 90 Ready to ship
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 750 Ready to ship
200mg USD 1350 Ready to ship
500mg USD 2850 Ready to ship
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Synonym: EC-5026; EC 5026; EC5026; BPN-19186; BPN 19186; BPN19186;

IUPAC/Chemical Name: (S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea

InChi Key: LHRXHTKENPCGSZ-NSHDSACASA-N

InChi Code: InChI=1S/C18H23F4N3O3/c1-3-11(2)16(26)25-8-6-12(7-9-25)23-17(27)24-13-4-5-15(14(19)10-13)28-18(20,21)22/h4-5,10-12H,3,6-9H2,1-2H3,(H2,23,24,27)/t11-/m0/s1

SMILES Code: O=C(NC1CCN(C([C@@H](C)CC)=O)CC1)NC2=CC=C(OC(F)(F)F)C(F)=C2

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: EC5026 (BPN-19186) is a non-opioid and soluble Epoxide Hydrolase (sEH) inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 250.0 616.69

Preparing Stock Solutions

The following data is based on the product molecular weight 405.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Takeshita AA, Hammock BD, Wagner KM. Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain. Front Pain Res (Lausanne). 2023 Jan 9;3:1100524. doi: 10.3389/fpain.2022.1100524. PMID: 36700145; PMCID: PMC9868926.


2: Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y, Hammock BD, Zheng Z, Liu Z, Chen G. Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharm Sin B. 2022 Mar;12(3):1377-1389. doi: 10.1016/j.apsb.2021.09.018. Epub 2021 Sep 22. PMID: 35530144; PMCID: PMC9072249.


3: Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Anal Methods. 2022 May 13;14(18):1810-1819. doi: 10.1039/d2ay00272h. PMID: 35481804; PMCID: PMC9116231.


4: Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. J Med Chem. 2021 May 13;64(9):5429-5446. doi: 10.1021/acs.jmedchem.0c01601. Epub 2021 May 4. PMID: 33945278; PMCID: PMC8634379.


5: Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. J Med Chem. 2021 Feb 25;64(4):1856-1872. doi: 10.1021/acs.jmedchem.0c01886. Epub 2021 Feb 7. PMID: 33550801; PMCID: PMC7917437.