PKG Drug G1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555755

CAS#: 374703-78-3

Description: PKG drug G1 is an activator of protein kinase GIα (PKGIα).

Chemical Structure

PKG Drug G1
CAS# 374703-78-3

Theoretical Analysis

MedKoo Cat#: 555755
Name: PKG Drug G1
CAS#: 374703-78-3
Chemical Formula: C13H11N3OS
Exact Mass: 257.0623
Molecular Weight: 257.311
Elemental Analysis: C, 60.68; H, 4.31; N, 16.33; O, 6.22; S, 12.46

Price and Availability

Size Price Availability Quantity
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5250.0 2 Weeks
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Synonym: PKG Drug G1

IUPAC/Chemical Name: 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-4-imidazolidinone


InChi Code: InChI=1S/C13H11N3OS/c1-7-9(6-11-12(17)16-13(18)15-11)8-4-2-3-5-10(8)14-7/h2-6,14H,1H3,(H2,15,16,17,18)/b11-6-

SMILES Code: O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Biological target: PKG agent G1 targets C42 of PKG Iα.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMF 25.0 97.16
DMSO 48.67 189.14
Ethanol 3.0 11.66

Preparing Stock Solutions

The following data is based on the product molecular weight 257.311 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Burgoyne, J.R., Prysyazhna, O., Richards, D.A., et al. Proof of principle for a novel class of antihypertensives that target the oxidative activation of PKG Iα (protein kinase G Iα). Hypertension 70(3), 577-586 (2017).

PKG Drug G1

10.0mg / Not available