BC-DXI01

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 593176

CAS#: 130217-49-1

Description: BC-DXI01 is a synthetic compound that specifically reduces the cellular levels of AIMP2-DX2 through selective degradation of the AIMP2-DX2 mRNA transcript. It has been found that BC-DXI01-mediated cell death positively correlates with AIMP2-DX2 expression in lung cancer cell lines.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 593176
Name: BC-DXI01
CAS#: 130217-49-1
Chemical Formula: 12H13NO5
Exact Mass: 251.0794
Molecular Weight: 251.238
Elemental Analysis: C, 57.37; H, 5.22; N, 5.58; O, 31.84


Synonym: BCDXI01; BC-DXI01; BC DXI01

IUPAC/Chemical Name: 4-Carboxymalonanilic acid ethyl ester; Benzoic acid, 4-​[(3-​ethoxy-​1,​3-​dioxopropyl)​amino]​-

InChi Key: CIIBCTSKJNXPLW-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13NO5/c1-2-18-11(15)7-10(14)13-9-5-3-8(4-6-9)12(16)17/h3-6H,2,7H2,1H3,(H,13,14)(H,16,17)

SMILES Code: O=C(O)C1=CC=C(NC(CC(OCC)=O)=O)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Lee HS, Kim DG, Oh YS, Kwon NH, Lee JY, Kim D, Park SH, Song JH, Lee S, Han JM, Park BJ, Lee J, Kim S. Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression. Biochem J. 2013 Sep 15;454(3):411-6. doi:10.1042/BJ20130550. PubMed PMID: 23815603.