WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593175
Description: G-631 is a tankyrase inhibitior and a potential anticancer agent.
MedKoo Cat#: 593175
Chemical Formula: C19H22F2N6O3
Exact Mass: 420.1721
Molecular Weight: 420.4208
Elemental Analysis: C, 54.28; H, 5.27; F, 9.04; N, 19.99; O, 11.42
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: G631; G-631;G 631
IUPAC/Chemical Name: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-1,5-dihydro-1-methyl-
InChi Key: NZHADTAZFJFNBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H22F2N6O3/c1-25-17-13(11-22-25)18(28)24-19(23-17)27-5-3-26(4-6-27)16-14(20)9-12(10-15(16)21)30-8-7-29-2/h9-11H,3-8H2,1-2H3,(H,23,24,28)
SMILES Code: O=C1NC(N2CCN(C3=C(F)C=C(OCCOC)C=C3F)CC2)=NC4=C1C=NN4C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 420.4208 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhong Y, Katavolos P, Nguyen T, Lau T, Boggs J, Sambrone A, Kan D, Merchant M, Harstad E, Diaz D, Costa M, Schutten M. Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1. Toxicol Pathol. 2016 Feb;44(2):267-78. doi: 10.1177/0192623315621192. Epub 2015 Dec 20. PubMed PMID: 26692561.