Danshenxinkun A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 330243

CAS#: 65907-75-7

Description: Danshenxinkun A is a natural diterpenoid isolated from the roots of Salvia miltiorrhiza Bge.


Chemical Structure

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Danshenxinkun A
CAS# 65907-75-7

Theoretical Analysis

MedKoo Cat#: 330243
Name: Danshenxinkun A
CAS#: 65907-75-7
Chemical Formula: C18H16O4
Exact Mass: 296.10
Molecular Weight: 296.322
Elemental Analysis: C, 72.96; H, 5.44; O, 21.60

Price and Availability

Size Price Availability Quantity
10mg USD 850 2 Weeks
50mg USD 1950 2 Weeks
100mg USD 3650 2 Weeks
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Synonym: Danshenxinkun A

IUPAC/Chemical Name: 1-hydroxy-2-(1-hydroxypropan-2-yl)-8-methylphenanthrene-3,4-dione

InChi Key: GRGPQNRHXNRJFL-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16O4/c1-9-4-3-5-12-11(9)6-7-13-15(12)18(22)17(21)14(16(13)20)10(2)8-19/h3-7,10,19-20H,8H2,1-2H3

SMILES Code: O=C1C(C(C)CO)=C(O)C2=C(C3=C(C=C2)C(C)=CC=C3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Danshenxinkun A is a natural compound that could be isolated from Tanshen and is used in the study for heart diseases.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 296.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Li B, Wu YR, Li L, Liu Y, Yan ZY. A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer's Disease. Molecules. 2022 Jul 12;27(14):4463. doi: 10.3390/molecules27144463. PMID: 35889336; PMCID: PMC9317794.


2: Lin HC, Ding HY, Chang WL. Two new fatty diterpenoids from Salvia miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. doi: 10.1021/np000345v. PMID: 11374966.


3: Li HB, Chen F. Preparative isolation and purification of six diterpenoids from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter- current chromatography. J Chromatogr A. 2001 Aug 3;925(1-2):109-14. doi: 10.1016/s0021-9673(01)01026-3. PMID: 11519796.


4: Luo HW, Wu BJ, Wu MY, Yong ZG, Jin Y. [Isolation and structure of danshenxinkun D]. Yao Xue Xue Bao. 1985 Jul;20(7):542-4. Chinese. PMID: 3841630.


5: Wang HQ, Yang LX, Chen XY, Yang PF, Chen RY. [Chemical Constituents from Salvia przewalskii Root]. Zhong Yao Cai. 2015 Jun;38(6):1197-201. Chinese. PMID: 26762059.


6: Jiang R, Zhang X, Li Y, Zhou H, Wang H, Wang F, Ma H, Cao L. Identification of the molecular mechanisms of Salvia miltiorrhiza relevant to the treatment of osteoarthritis based on network pharmacology. Discov Med. 2020 Sep- Oct;30(160):83-95. PMID: 33382964.


7: Lin LZ, Wang XM, Huang XL, Huang Y, Yang BJ. [A new diterpenoid quinone dehydromiltirone]. Yao Xue Xue Bao. 1988 Apr;23(4):273-5. Chinese. PMID: 3176980.


8: Shu Y, Zhu W, Hu Q. [Chemical constituents of tissue cultures of Salvia miltiorrhiza Bunge]. Zhongguo Zhong Yao Za Zhi. 1998 Mar;23(3):166-7, 192. Chinese. PMID: 11596236.


9: Liu M, Li YG, Zhang F, Yang L, Chou GX, Wang ZT, Hu ZB. Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS). J Sep Sci. 2007 Sep;30(14):2256-67. doi: 10.1002/jssc.200700149. PMID: 17683043.