BU99008

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555742

CAS#: 108796-88-9

Description: BU99008 is non-radiolabled compound. 11C-BU99008 is a PET Ligand for the imidazoline2 Binding Sites in Rhesus Brain.


Chemical Structure

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BU99008
CAS# 108796-88-9

Theoretical Analysis

MedKoo Cat#: 555742
Name: BU99008
CAS#: 108796-88-9
Chemical Formula: C12H13N3
Exact Mass: 199.11
Molecular Weight: 199.257
Elemental Analysis: C, 72.33; H, 6.58; N, 21.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BU99008; BU-99008; BU 99008;

IUPAC/Chemical Name: 2-(4,5-Dihydro-1H-imidazol-2-yl)-1-methyl-1H-indole

InChi Key: LOFCLFKSYRAAFZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13N3/c1-15-10-5-3-2-4-9(10)8-11(15)12-13-6-7-14-12/h2-5,8H,6-7H2,1H3,(H,13,14)

SMILES Code: CN1C(C2=NCCN2)=CC3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 199.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wilson H, Dervenoulas G, Pagano G, Tyacke RJ, Polychronis S, Myers J, Gunn RN, Rabiner EA, Nutt D, Politis M. Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease: an in vivo11C-BU99008 PET study. Brain. 2019 Oct 1;142(10):3116-3128. doi: 10.1093/brain/awz260. PMID: 31504212.

2: Kawamura K, Yamasaki T, Zhang Y, Wakizaka H, Hatori A, Xie L, Fujinaga M, Zhang MR. Change in the Binding of [11C]BU99008 to Imidazoline I2 Receptor Using Brain PET in Zucker Rats. Mol Imaging Biol. 2019 Feb;21(1):105-112. doi: 10.1007/s11307-018-1206-y. PMID: 29736564.

3: Venkataraman AV, Keat N, Myers JF, Turton S, Mick I, Gunn RN, Rabiner EA, Passchier J, Parker CA, Tyacke RJ, Nutt DJ. First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site. EJNMMI Res. 2018 Jul 30;8(1):71. doi: 10.1186/s13550-018-0429-x. PMID: 30062395; PMCID: PMC6066589.

4: Tyacke RJ, Myers JFM, Venkataraman A, Mick I, Turton S, Passchier J, Husbands SM, Rabiner EA, Gunn RN, Murphy PS, Parker CA, Nutt DJ. Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Site in Human Brain. J Nucl Med. 2018 Oct;59(10):1597-1602. doi: 10.2967/jnumed.118.208009. Epub 2018 Mar 9. PMID: 29523627.

5: Kawamura K, Shimoda Y, Yui J, Zhang Y, Yamasaki T, Wakizaka H, Hatori A, Xie L, Kumata K, Fujinaga M, Ogawa M, Kurihara Y, Nengaki N, Zhang MR. A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus. Nucl Med Biol. 2017 Feb;45:1-7. doi: 10.1016/j.nucmedbio.2016.10.005. Epub 2016 Oct 26. PMID: 27835825.

6: Kawamura K, Shimoda Y, Kumata K, Fujinaga M, Yui J, Yamasaki T, Xie L, Hatori A, Wakizaka H, Kurihara Y, Ogawa M, Nengaki N, Zhang MR. In vivo evaluation of a new ¹⁸F-labeled PET ligand, [¹⁸F]FEBU, for the imaging of I₂-imidazoline receptors. Nucl Med Biol. 2015 Apr;42(4):406-12. doi: 10.1016/j.nucmedbio.2014.12.014. Epub 2014 Dec 26. PMID: 25583220.

7: Parker CA, Nabulsi N, Holden D, Lin SF, Cass T, Labaree D, Kealey S, Gee AD, Husbands SM, Quelch D, Carson RE, Nutt DJ, Huang Y, Tyacke RJ. Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain. J Nucl Med. 2014 May;55(5):838-44. doi: 10.2967/jnumed.113.131854. Epub 2014 Apr 7. PMID: 24711648.

8: Kealey S, Turner EM, Husbands SM, Salinas CA, Jakobsen S, Tyacke RJ, Nutt DJ, Parker CA, Gee AD. Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008. J Nucl Med. 2013 Jan;54(1):139-44. doi: 10.2967/jnumed.112.108258. Epub 2012 Dec 5. PMID: 23223380.

9: Tyacke RJ, Fisher A, Robinson ES, Grundt P, Turner EM, Husbands SM, Hudson AL, Parker CA, Nutt DJ. Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site. Synapse. 2012 Jun;66(6):542-51. doi: 10.1002/syn.21541. Epub 2012 Feb 22. PMID: 22290740.