WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593169
Description: JMX0312 is a salicylamide derivative used as a potent inhibitor of HAdV infection. JMX0312 showed significantly improved anti-HAdV activities with nanomolar to submicromolar IC50 values and high selectivity indexes (SI > 100), indicating better safety windows, compared to those of the lead compound niclosamide.
MedKoo Cat#: 593169
Chemical Formula: C14H8ClF4NO2
Exact Mass: 333.018
Molecular Weight: 333.6666
Elemental Analysis: C, 50.40; H, 2.42; Cl, 10.62; F, 22.78; N, 4.20; O, 9.59
This product is not in stock, which may be available by custom synthesis.
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Synonym: JMX-0312; JMX0312; JMX 0312
IUPAC/Chemical Name: Benzamide, 5-chloro-N-[3-fluoro-5-(trifluoromethyl)phenyl]-2-hydroxy-
InChi Key: ZNPREQSETWFCPD-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H8ClF4NO2/c15-8-1-2-12(21)11(5-8)13(22)20-10-4-7(14(17,18)19)3-9(16)6-10/h1-6,21H,(H,20,22)
SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC(F)=C1)C2=CC(Cl)=CC=C2O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 333.6666 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xu J, Berastegui-Cabrera J, Chen H, Pachón J, Zhou J, Sánchez-Céspedes J. Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection. J Med Chem. 2020 Feb 28. doi: 10.1021/acs.jmedchem.9b01950. [Epub ahead of print] PubMed PMID: 32045239.