WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533794
Description: MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
MedKoo Cat#: 533794
Chemical Formula: C23H27N3O2
Exact Mass: 377.2103
Molecular Weight: 377.488
Elemental Analysis: C, 73.18; H, 7.21; N, 11.13; O, 8.48
Synonym: MCU-i4; MCUi4; MCU i4;
IUPAC/Chemical Name: Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
InChi Key: RIWXBJCWHVMATR-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H,5-7H2,1-4H3,(H,24,25)
SMILES Code: O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 377.488 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, Techer- Etienne V, Haasen D, Oberhauser B, Schleeger S, Minetti G, Moro S, Rizzuto R, De Stefani D, Fornaro M, Mammucari C. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. doi: 10.1016/j.celrep.2020.01.081. PMID: 32075766; PMCID: PMC7034061.