WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533766


Description: B026 is a novel, highly selective, potent inhibitor of p300/CBP histone acetyltransferases (HAT) with IC50 values of 1.8 nM to p300 and 9.5 nM to CBP enzyme inhibitory activity.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 533766
Name: B026
Chemical Formula: C28H24F4N4O4
Exact Mass: 556.1734
Molecular Weight: 556.5176
Elemental Analysis: C, 60.43; H, 4.35; F, 13.66; N, 10.07; O, 11.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: B026; B-026; B 026

IUPAC/Chemical Name: (S)-1'-(2-((S)-7-Fluoro-3-(trifluoromethyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)-2-oxoethyl)-5-(1-methyl-1H-pyrazol-4-yl)-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-2',5'-dione


InChi Code: InChI=1S/C28H24F4N4O4/c1-34-12-19(11-33-34)16-2-4-21-17(8-16)6-7-27(21)10-24(37)36(26(27)39)14-25(38)35-13-18-9-20(29)3-5-22(18)40-15-23(35)28(30,31)32/h2-5,8-9,11-12,23H,6-7,10,13-15H2,1H3/t23-,27-/m0/s1

SMILES Code: O=C([C@]12CCC3=C1C=CC(C4=CN(C)N=C4)=C3)N(CC(N5[C@H](C(F)(F)F)COC6=CC=C(F)C=C6C5)=O)C(C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 556.5176 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang Y, Zhang R, Li Z, Mei L, Wan S, Ding H, Chen Z, Xing J, Feng H, Han J, Jiang H, Zheng M, Luo C, Zhou B. Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. J Med Chem. 2020 Feb 13;63(3):1337-1360. doi: 10.1021/acs.jmedchem.9b01721. Epub 2020 Jan 28. PMID: 31910017.

2: Matheson L, Wilding S, Wagland R, Nayoan J, Rivas C, Downing A, Wright P, Brett J, Kearney T, Cross W, Glaser A, Gavin A, Watson E. The psychological impact of being on a monitoring pathway for localised prostate cancer: A UK-wide mixed methods study. Psychooncology. 2019 Jul;28(7):1567-1575. doi: 10.1002/pon.5133. Epub 2019 Jun 10. PMID: 31132801.

3: Haas NL, Coute RA, Hsu CH, Cranford JA, Neumar RW. Descriptive analysis of extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest-An ELSO registry study. Resuscitation. 2017 Oct;119:56-62. doi: 10.1016/j.resuscitation.2017.08.003. Epub 2017 Aug 5. PMID: 28789990; PMCID: PMC6040225.

4: Chen XS, DI JC, Ma XJ, Liu XM. [Analysis on linkage inheritance of sub-red plant mutant from upland cotton]. Yi Chuan. 2009 Aug;31(8):855-8. Chinese. doi: 10.3724/sp.j.1005.2009.00855. PMID: 19689948.