WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533705
CAS#: N/A
Description: H109 is a novel potent dual inhibitor of MDMX and MDM2.
MedKoo Cat#: 533705
Name: H109
CAS#: N/A
Chemical Formula: C36H34ClN5O8
Exact Mass: 699.2096
Molecular Weight: 700.145
Elemental Analysis: C, 61.76; H, 4.89; Cl, 5.06; N, 10.00; O, 18.28
This product is not in stock, which may be available by custom synthesis.
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Synonym: H109; H-109; H 109
IUPAC/Chemical Name: 4-((4S,5R)-2-(2-(tert-Butoxy)-4-(2-carboxyacetyl)phenyl)-5-(6-chloro-1H-indol-3-yl)-1-(3-oxopiperazine-1-carbonyl)-4,5-dihydro-1H-imidazol-4-yl)benzoic acid
InChi Key: KHMWWQBTTNMMCG-AJQTZOPKSA-N
InChi Code: InChI=1S/C36H34ClN5O8/c1-36(2,3)50-28-14-21(27(43)16-30(45)46)8-10-24(28)33-40-31(19-4-6-20(7-5-19)34(47)48)32(25-17-39-26-15-22(37)9-11-23(25)26)42(33)35(49)41-13-12-38-29(44)18-41/h4-11,14-15,17,31-32,39H,12-13,16,18H2,1-3H3,(H,38,44)(H,45,46)(H,47,48)/t31-,32+/m0/s1
SMILES Code: O=C(O)C1=CC=C([C@@H]2N=C(C3=CC=C(C(CC(O)=O)=O)C=C3OC(C)(C)C)N(C(N4CC(NCC4)=O)=O)[C@@H]2C5=CNC6=C5C=CC(Cl)=C6)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 700.145 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
