WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585445
CAS#: 1192171-69-9
Description: Vonafexor, also known as EYP001, is a farnesoid X receptor agonist. Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) for which therapy is suboptimal. The farnesoid-X-receptor (FXR) and the G protein bile acid receptor (GPBAR)1 are two bile acid-activated receptors that exert regulatory effects on lipid, glucose, energy, and immune homeostasis. GPBAR1 and FXR ligands have shown efficacy in reversing steatohepatitis and fibrosis in preclinical models of NASH.
MedKoo Cat#: 585445
Name: Vonafexor
CAS#: 1192171-69-9
Chemical Formula: C19H15Cl3N2O5S
Exact Mass: 487.9767
Molecular Weight: 489.748
Elemental Analysis: C, 46.60; H, 3.09; Cl, 21.72; N, 5.72; O, 16.33; S, 6.55
Related CAS #: 1192171-69-9
Synonym: Vonafexor; EYP001; EYP-001; EYP 001;
IUPAC/Chemical Name: 4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid
InChi Key: XLGQSYUNOIJBNR-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H15Cl3N2O5S/c20-12-2-1-3-13(21)18(12)30(27,28)24-8-6-23(7-9-24)14-4-5-15-11(17(14)22)10-16(29-15)19(25)26/h1-5,10H,6-9H2,(H,25,26)
SMILES Code: O=C(C(O1)=CC2=C1C=CC(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=C2Cl)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 489.748 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Orrico M, Ronchey S, Setacci C, et al. The "Destino-guided BEVAR" to Catheterize Downward Branches from a Femoral Access: Technical Note and Case Report. Ann Vasc Surg. 2019;57:266-271. doi:10.1016/j.avsg.2018.09.044
