(±)-β-Tocopherol
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MedKoo CAT#: 574279

CAS#: 148-03-8

Description: (±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits LPS-induced COX-2 gene expression. Unlike (±)-α-tocopherol, (±)-β-tocopherol does not inhibit smooth muscle cell proliferation, decrease PKC activity, increase phosphoprotein phosphatase 2A (PP2A) activity, or modify expression of the α-tropomyosin gene.

Chemical Structure

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(±)-β-Tocopherol
CAS# 148-03-8
Instruction

Theoretical Analysis

MedKoo Cat#: 574279
Name: (±)-β-Tocopherol
CAS#: 148-03-8
Chemical Formula: C28H48O2
Exact Mass: 416.37
Molecular Weight: 416.690
Elemental Analysis: C, 80.71; H, 11.61; O, 7.68

Price and Availability

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50mg USD 390
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Synonym: (±)-β-Tocopherol, DL-β-Tocopherol, rac-β-Tocopherol

IUPAC/Chemical Name: (2R)-rel-3,4-dihydro-2,5,8-trimethyl-2-[4R,8R,12-trimethyltridecyl]-2H-1-benzopyran-6-ol

InChi Key: WGVKWNUPNGFDFJ-DQCZWYHMSA-N

InChi Code: InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-24(6)26(29)19-23(5)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1

SMILES Code: CC1=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C(C)C(O)=C1

Appearance: A solution in hexane

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 416.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Brigelius-Flohé, R., and Traber, M.G. Vitamin E: Function and metabolism. FASEB J. 13(10), 1145-1155 (1999).

2. Chen, C.-R., Chao, L.-H., Pan, M.-H., et al. Tocopherols and triterpenoids from Sida acuta. J. Chin. Chem. Soc. 54(1), 41-45 (2007).

3. Murakami, Y., Kawata, A., Koh, T., et al. Inhibitory effects of tocopherols on expression of the cyclooxygenase-2 gene in RAW264.7 cells stimulated by lipopolysaccharide, tumor necrosis factor-α or Porphyromonas gingivalis fimbriae. In Vivo 27(4), 451-458 (2013).