WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533532
CAS#: 2414418-49-6
Description: ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.
MedKoo Cat#: 533532
Name: ZNL-02-096
CAS#: 2414418-49-6
Chemical Formula: C42H45N11O6
Exact Mass: 799.3554
Molecular Weight: 799.893
Elemental Analysis: C, 63.07; H, 5.67; N, 19.26; O, 12.00
Synonym: ZNL-02-096; ZNL 02-096; ZNL02-096; ZNL-02096; ZNL 02096; ZNL02096;
IUPAC/Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key: LZUDSNUROXNVPH-UHFFFAOYSA-N
InChi Code: InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)
SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCN4CCN(C5=CC=C(NC6=NC=C7C(N(C8=NC(C(C)(O)C)=CC=C8)N(CC=C)C7=O)=N6)C=C5)CC4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.99 | 50.0 |
The following data is based on the product molecular weight 799.893 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Li Z, Pinch BJ, Olson CM, Donovan KA, Nowak RP, Mills CE, Scott DA, Doctor ZM, Eleuteri NA, Chung M, Sorger PK, Fischer ES, Gray NS. Development and Characterization of a Wee1 Kinase Degrader. Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9. doi: 10.1016/j.chembiol.2019.10.013. Epub 2019 Nov 14. PMID: 31735695; PMCID: PMC6980656.
