WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574239
Description: 1233B is a fungal metabolite and open-ring derivative of L-659,699 (hymeglusin) that lacks HMG-CoA synthase inhibitory activity.
MedKoo Cat#: 574239
Chemical Formula: C18H30O6
Exact Mass: 342.2042
Molecular Weight: 342.43
Elemental Analysis: C, 63.14; H, 8.83; O, 28.03
Synonym: 1233B, L 660,282
IUPAC/Chemical Name: 12-hydroxy-13-(hydroxymethyl)-3,5,7-trimethyl-2,4-tetradecadienedioic acid
InChi Key: QFZISQBFEIXWDM-UTLPMFLDSA-N
InChi Code: InChI=1S/C18H30O6/c1-12(8-13(2)9-14(3)10-17(21)22)6-4-5-7-16(20)15(11-19)18(23)24/h9-10,12,15-16,19-20H,4-8,11H2,1-3H3,(H,21,22)(H,23,24)/b13-9+,14-10+
SMILES Code: OC(/C=C(C)/C=C(C)/CC(C)CCCCC(O)C(CO)C(O)=O)=O
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 342.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Aldridge, D.C., Giles, D., and Turner, W.B. Antibiotic 1233A: A fungal β-lactone. J. Chem. Soc. C Organic 23(0), 3888-3891 (1971).
2. Greenspan, M.D., Yudkovitz, J.B., Lo, C.Y., et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc. Natl. Acad. Sci. U.S.A. 84(21), 7488-7492 (1987).