WR 243251

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585422

CAS#: 80092-76-8

Description: WR 243251 is a dihydroacridinedione with strong potential as a blood schizonticidal agent.

Chemical Structure

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WR 243251
CAS# 80092-76-8
Instruction

Theoretical Analysis

MedKoo Cat#: 585422
Name: WR 243251
CAS#: 80092-76-8
Chemical Formula: C24H24Cl3N3O
Exact Mass: 475.10
Molecular Weight: 476.826
Elemental Analysis: C, 60.45; H, 5.07; Cl, 22.30; N, 8.81; O, 3.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WR 243251; WR243251; WR-243251

IUPAC/Chemical Name: 7-chloro-3-(2,4-dichlorophenyl)-1-[3-(dimethylamino)propylimino]-2,3,4,10-tetrahydroacridin-9-one

InChi Key: QPVVEWNCFBEZTH-SGWCAAJKSA-N

InChi Code: InChI=1S/C24H24Cl3N3O/c1-30(2)9-3-8-28-21-10-14(17-6-4-16(26)13-19(17)27)11-22-23(21)24(31)18-12-15(25)5-7-20(18)29-22/h4-7,12-14H,3,8-11H2,1-2H3,(H,29,31)/b28-21+

SMILES Code: O=C1C2=C(C=CC(Cl)=C2)NC3=C1/C(CC(C4=CC=C(Cl)C=C4Cl)C3)=N/CCCN(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 476.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL. Short report: floxacrine analog WR 243251 inhibits hematin polymerization. Am J Trop Med Hyg. 2001 Jul;65(1):19-20. PubMed PMID: 11504401.

2: Berman J, Brown L, Miller R, Andersen SL, McGreevy P, Schuster BG, Ellis W, Ager A, Rossan R. Antimalarial activity of WR 243251, a Dihydroacridinedione. Antimicrob Agents Chemother. 1994 Aug;38(8):1753-6. PubMed PMID: 7986005; PubMed Central PMCID: PMC284632.

3: Milhous WK. Development of new drugs for chemoprophylaxis of malaria. Med Trop (Mars). 2001;61(1):48-50. Review. PubMed PMID: 11584654.

4: Coleman RE, Polsa N, Eikarat N, Kollars TM Jr, Sattabongkot J. Prevention of sporogony of Plasmodium vivax in Anopheles dirus mosquitoes by transmission-blocking antimalarials. Am J Trop Med Hyg. 2001 Sep;65(3):214-8. PubMed PMID: 11561707.

5: Coleman RE, Clavin AM, Milhous WK. Gametocytocidal and sporontocidal activity of antimalarials against Plasmodium berghei ANKA in ICR Mice and Anopheles stephensi mosquitoes. Am J Trop Med Hyg. 1992 Feb;46(2):169-82. PubMed PMID: 1539752.

6: Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J Med Chem. 2011 Jul 14;54(13):4399-426. doi: 10.1021/jm200015a. Epub 2011 Jun 16. PubMed PMID: 21630666.

7: Milhous W. Development of new drugs for chemoprophylaxis of malaria. Bull Soc Pathol Exot. 2001 Jul;94(2 Pt 2):149-51. PubMed PMID: 16579068.

8: Suswam E, Kyle D, Lang-Unnasch N. Plasmodium falciparum: the effects of atovaquone resistance on respiration. Exp Parasitol. 2001 Aug;98(4):180-7. PubMed PMID: 11560411.

9: Kesten SJ, Degnan MJ, Hung J, McNamara DJ, Ortwine DF, Uhlendorf SE, Werbel LM. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures. J Med Chem. 1992 Sep 18;35(19):3429-47. PubMed PMID: 1404226.