ABT-724 (hydrochloride)
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MedKoo CAT#: 471047

CAS#: 587870-77-7 (HCl)

Description: ABT-724 acts as a dopamine agonist and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile dysfunction. It continues to be used in scientific research into the function of the D4 receptor.


Chemical Structure

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ABT-724 (hydrochloride)
CAS# 587870-77-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 471047
Name: ABT-724 (hydrochloride)
CAS#: 587870-77-7 (HCl)
Chemical Formula: C17H22Cl3N5
Exact Mass:
Molecular Weight: 402.75
Elemental Analysis: C, 50.70; H, 5.51; Cl, 26.41; N, 17.39

Price and Availability

Size Price Availability Quantity
10.0mg USD 280.0 2 Weeks
50.0mg USD 630.0 2 Weeks
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Related CAS #: 587870-77-7 (HCl)   70006-24-5 (free base)  

Synonym: ABT-724 (hydrochloride), ABT724 (hydrochloride), ABT 724 (hydrochloride), ABT-724 (HCl)

IUPAC/Chemical Name: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride

InChi Key: AZFUVPBLKQGSRI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H

SMILES Code: [H]Cl.[H]Cl.[H]Cl.C1(CN2CCN(C3=NC=CC=C3)CC2)=NC4=CC=CC=C4N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Cowart, M., Latshaw, S.P., Bhatia, P., et al. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J. Med. Chem. 47(15), 3853-3864 (2004).

2. Stewart AO. et. al. Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J Med Chem. 2004 Apr 22;47(9):2348-55.

3. Yin, P., Cao, A.-H., Yu, L., et al. ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Neurosci. Lett. 580, 142-146 (2014).

4. Sanna, F., Contini, A., Melis, M.R., et al. Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats. Pharmacol. Biochem. Behav. 137, 110-118 (2015).