KY-226
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MedKoo CAT#: 555704

CAS#: 1621673-53-7

Description: KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 650 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2150 2 Weeks
1g USD 3250 2 Weeks
2g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-08. Prices are subject to change without notice.

KY-226, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555704
Name: KY-226
CAS#: 1621673-53-7
Chemical Formula: C27H31NO3S2
Exact Mass: 481.1745
Molecular Weight: 481.669
Elemental Analysis: C, 67.33; H, 6.49; N, 2.91; O, 9.96; S, 13.31


Synonym: KY-226; KY 226; KY226;

IUPAC/Chemical Name: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide

InChi Key: MKXMABKUVSOEJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)

SMILES Code: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Sun M, Shinoda Y, Fukunaga K. KY-226 Protects Blood-brain Barrier Function
Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. Neuroscience. 2019 Feb
10;399:89-102. doi: 10.1016/j.neuroscience.2018.12.024. Epub 2018 Dec 21. PubMed
PMID: 30579831.

2: Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H.
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor
KY-226 on experimental diabetes and obesity via enhancements in insulin and
leptin signaling in mice. J Pharmacol Sci. 2018 May;137(1):38-46. doi:
10.1016/j.jphs.2018.03.001. Epub 2018 Mar 6. PubMed PMID: 29731242.

3: Sun M, Izumi H, Shinoda Y, Fukunaga K. Neuroprotective effects of protein
tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice. Brain
Res. 2018 Sep 1;1694:1-12. doi: 10.1016/j.brainres.2018.04.029. Epub 2018 Apr 26.
PubMed PMID: 29705606.