KY-226
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MedKoo CAT#: 555704

CAS#: 1621673-53-7

Description: KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation.


Chemical Structure

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KY-226
CAS# 1621673-53-7

Theoretical Analysis

MedKoo Cat#: 555704
Name: KY-226
CAS#: 1621673-53-7
Chemical Formula: C27H31NO3S2
Exact Mass: 481.1745
Molecular Weight: 481.669
Elemental Analysis: C, 67.33; H, 6.49; N, 2.91; O, 9.96; S, 13.31

Price and Availability

Size Price Availability Quantity
10.0mg USD 190.0 Ready to ship
25.0mg USD 350.0 Ready to ship
50.0mg USD 550.0 Ready to ship
100.0mg USD 950.0 Ready to ship
200.0mg USD 1650.0 Ready to ship
500.0mg USD 2950.0 Ready to ship
1.0g USD 4250.0 Ready to ship
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Synonym: KY-226; KY 226; KY226;

IUPAC/Chemical Name: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide

InChi Key: MKXMABKUVSOEJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)

SMILES Code: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1

Appearance: Fluffy white solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 481.669 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sun M, Shinoda Y, Fukunaga K. KY-226 Protects Blood-brain Barrier Function
Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. Neuroscience. 2019 Feb
10;399:89-102. doi: 10.1016/j.neuroscience.2018.12.024. Epub 2018 Dec 21. PubMed
PMID: 30579831.

2: Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H.
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor
KY-226 on experimental diabetes and obesity via enhancements in insulin and
leptin signaling in mice. J Pharmacol Sci. 2018 May;137(1):38-46. doi:
10.1016/j.jphs.2018.03.001. Epub 2018 Mar 6. PubMed PMID: 29731242.

3: Sun M, Izumi H, Shinoda Y, Fukunaga K. Neuroprotective effects of protein
tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice. Brain
Res. 2018 Sep 1;1694:1-12. doi: 10.1016/j.brainres.2018.04.029. Epub 2018 Apr 26.
PubMed PMID: 29705606.

KY-226

10.0mg / USD 190.0