KY-226
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555704

CAS#: 1621673-53-7

Description: KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation.


Price and Availability

Size
Price

50mg
USD 650
500mg
USD 2150
Size
Price

100mg
USD 950
1g
USD 3250
Size
Price

200mg
USD 1450
2g
USD 5850

KY-226, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555704
Name: KY-226
CAS#: 1621673-53-7
Chemical Formula: C27H31NO3S2
Exact Mass: 481.1745
Molecular Weight: 481.669
Elemental Analysis: C, 67.33; H, 6.49; N, 2.91; O, 9.96; S, 13.31


Synonym: KY-226; KY 226; KY226;

IUPAC/Chemical Name: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide

InChi Key: MKXMABKUVSOEJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)

SMILES Code: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Sun M, Shinoda Y, Fukunaga K. KY-226 Protects Blood-brain Barrier Function
Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. Neuroscience. 2019 Feb
10;399:89-102. doi: 10.1016/j.neuroscience.2018.12.024. Epub 2018 Dec 21. PubMed
PMID: 30579831.

2: Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H.
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor
KY-226 on experimental diabetes and obesity via enhancements in insulin and
leptin signaling in mice. J Pharmacol Sci. 2018 May;137(1):38-46. doi:
10.1016/j.jphs.2018.03.001. Epub 2018 Mar 6. PubMed PMID: 29731242.

3: Sun M, Izumi H, Shinoda Y, Fukunaga K. Neuroprotective effects of protein
tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice. Brain
Res. 2018 Sep 1;1694:1-12. doi: 10.1016/j.brainres.2018.04.029. Epub 2018 Apr 26.
PubMed PMID: 29705606.