LH1307
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471041

CAS#: 2375720-38-8

Description: LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1.


Price and Availability

Size
Price

5mg
USD 520
Size
Price

10mg
USD 900
Size
Price

LH1307, purity > 98%, is in stock. Current shipping out time for small quantity is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Bulk quantity may be available through custom synthesis.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 471041
Name: LH1307
CAS#: 2375720-38-8
Chemical Formula: C54H58N8O6
Exact Mass: 914.4479
Molecular Weight: 915.11
Elemental Analysis: C, 70.88; H, 6.39; N, 12.25; O, 10.49


Synonym: LH1307, LH 1307, LH-1307

IUPAC/Chemical Name: N,N'-(((((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(methylene))bis(oxy))bis(2-((5-cyanopyridin-3-yl)methoxy)-5-methyl-4,1-phenylene))bis(methylene))bis(azanediyl))bis(ethane-2,1-diyl))diacetamide

InChi Key: RNCINFJGGSQEHN-UHFFFAOYSA-N

InChi Code: InChI=1S/C54H58N8O6/c1-35-17-47(29-57-13-15-61-39(5)63)53(65-31-43-19-41(23-55)25-59-27-43)21-51(35)67-33-45-9-7-11-49(37(45)3)50-12-8-10-46(38(50)4)34-68-52-22-54(66-32-44-20-42(24-56)26-60-28-44)48(18-36(52)2)30-58-14-16-62-40(6)64/h7-12,17-22,25-28,57-58H,13-16,29-34H2,1-6H3,(H,61,63)(H,62,64)

SMILES Code: CC1=C(COC2=C(C)C=C(CNCCNC(C)=O)C(OCC3=CC(C#N)=CN=C3)=C2)C=CC=C1C4=CC=CC(COC5=C(C)C=C(CNCCNC(C)=O)C(OCC6=CC(C#N)=CN=C6)=C5)=C4C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263, 2019