Villalstonine

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585375

CAS#: 2723-56-0

Description: Villalstonine is a bisindole alkaloid isolated from Alstonia with in vitro antiplasmodial activity.


Price and Availability

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Pricing updated 2020-02-28. Prices are subject to change without notice.

Villalstonine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585375
Name: Villalstonine
CAS#: 2723-56-0
Chemical Formula: C41H48N4O4
Exact Mass: 660.3676
Molecular Weight: 660.859
Elemental Analysis: C, 74.52; H, 7.32; N, 8.48; O, 9.68


Synonym: Villalstonine

IUPAC/Chemical Name: methyl (27Z)-27-ethylidene-8,21,40-trimethyl-20,22-dioxa-8,25,30,40-tetrazaundecacyclo[23.11.2.16,17.124,28.01,23.03,21.04,18.07,15.09,14.023,30.031,36]tetraconta-7(15),9,11,13,31,33,35-heptaene-29-carboxylate

InChi Key: XXNYZYBYNFRERU-TXNBCWFRSA-N

InChi Code: InChI=1S/C41H48N4O4/c1-6-23-21-44-16-15-40-20-30-26-17-34-36-27(24-11-7-9-13-31(24)43(36)4)18-33(42(34)3)28(26)22-48-39(30,2)49-41(40)35(44)19-25(23)37(38(46)47-5)45(41)32-14-10-8-12-29(32)40/h6-14,25-26,28,30,33-35,37H,15-22H2,1-5H3/b23-6+

SMILES Code: O=C(C1C(C2)/C(CN3C2C45OC6(C)OCC7C(N8C)CC9=C(N(C)C%10=CC=CC=C9%10)C8CC7C6CC(CC3)4C%11=CC=CC=C%11N15)=C/C)OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Keawpradub N, Kirby GC, Steele JC, Houghton PJ. Antiplasmodial activity of extracts and alkaloids of three Alstonia species from Thailand. Planta Med. 1999 Dec;65(8):690-4. PubMed PMID: 10630106.

2: Keawpradub N, Eno-Amooquaye E, Burke PJ, Houghton PJ. Cytotoxic activity of indole alkaloids from Alstonia macrophylla. Planta Med. 1999 May;65(4):311-5. PubMed PMID: 10364834.

3: Keawpradub N, Houghton PJ, Eno-Amooquaye E, Burke PJ. Activity of extracts and alkaloids of thai Alstonia species against human lung cancer cell lines. Planta Med. 1997 Apr;63(2):97-101. PubMed PMID: 9140219.