Viaspan

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MedKoo CAT#: 585372

CAS#: 306277-70-3

Description: Viaspan is the preferred medium for cold storage of livers and kidneys, as well as pancreas.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-02-28. Prices are subject to change without notice.

Viaspan is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585372
Name: Viaspan
CAS#: 306277-70-3
Chemical Formula: C18H32O16; MgO4S; C22H44O17; C12H22O12; C10H17N3O6S; C5H4N4O; K3O4P; C10H13N5O4
Exact Mass: 504.169
Molecular Weight: 504.438
Elemental Analysis: C, 42.86; H, 6.39; O, 50.75; Mg, 20.19; O, 53.17; S, 26.64; C, 45.51; H, 7.64; O, 46.85; C, 40.23; H, 6.19; O, 53.58; C, 39.08; H, 5.58; N, 13.67; O, 31.24; S, 10.43; C, 44.12; H, 2.96; N, 41.16; O, 11.75; K, 55.26; O, 30.15; P, 14.59; C, 44.94; H, 4.90; N, 26.21; O, 23.95


Synonym: Viaspan; Belzer UW; Bel-Gen; StoreProtect

IUPAC/Chemical Name: 4-O-beta-galactopyranosyl-D-gluconic acid; Potassium phosphate; Magnesium sulfate; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-3,4,5-triol; (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid; 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one; (2S,3R,4S,5R,6R)-6-(Hydroxymethyl)oxane-2,3,4,5-tetrol;2-[[(2R,3S,4S,5R,6S)-3,4,5,6-tetrakis(2-hydroxyethoxy)oxan-2-yl]methoxy]ethanol

InChi Key: AUKCDCIYOMVDTP-ZFSDGVPGSA-I

InChi Code: InChI=1S/C18H32O16.C16H32O11.C12H22O12.C10H13N5O4.C10H17N3O6S.C6H12O6.C5H4N4O.3K.Mg.H3O4P.H2O4S/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18;1-11(21)26-10-12-13(22-6-2-17)14(23-7-3-18)15(24-8-4-19)16(27-12)25-9-5-20;13-1-3(15)10(7(18)8(19)11(21)22)24-12-9(20)6(17)5(16)4(2-14)23-12;11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10;11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;7-1-2-3(8)4(9)5(10)6(11)12-2;10-5-3-1-8-9-4(3)6-2-7-5;;;;;2*1-5(2,3)4/h5-17,19-29H,1-4H2;11-21H,2-10H2,1H3;3-10,12-20H,1-2H2,(H,21,22);2-4,6-7,10,16-18H,1H2,(H2,11,12,13);5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);2-11H,1H2;1-2H,(H2,6,7,8,9,10);;;;;(H3,1,2,3,4);(H2,1,2,3,4)/q;;;;;;;3*+1;+2;;/p-5/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+;11-,12+,13-,14-,15+,16-;3-,4-,5+,6+,7-,8-,9-,10-,12+;4-,6-,7-,10-;5-,6-;;;;;;;;/m10110......../s1

SMILES Code: O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](CO)[C@H]1O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O[C@H]4[C@@H]([C@H]([C@H]([C@@H](CO)O4)O)O)O)O)C(O)=O.O=P([O-])([O-])[O-].O=S([O-])([O-])=O.OC5OC(CO)C(O)C(O)C5O.C[C@@H](O)OC[C@H]6O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@H]6OCCO.O=C7C8=C(NN=C8)N=CN7.O=C(O)[C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CS)=O.O[C@H]9[C@@H](O[C@]%10(CO)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO[C@H]%11O[C@H](CO)[C@H](O)[C@H](O)[C@H]%11O)[C@@H](O)[C@@H]9O.[K+].[K+].[K+].[Mg+2]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Montiel-Casado MC, Pérez-Daga JA, Blanco-Elena JA, Aranda-Narváez JM, Sánchez-Pérez B, Cabello-Díaz M, Ruiz-Esteban P, León-Díaz FJ, Gutiérrez-de la Fuente C, Santoyo-Santoyo J. Pancreas Preservation With Viaspan, Celsior, and Custodiol Solutions: An Initial Experience. Transplant Proc. 2016 Nov;48(9):3040-3042. doi: 10.1016/j.transproceed.2016.07.042. PubMed PMID: 27932142.

2: Pizarro MD, Mediavilla MG, Berardi F, Tiribelli C, Rodríguez JV, Mamprin ME. Cold storage of liver microorgans in ViaSpan and BG35 solutions: study of ammonia metabolism during normothermic reoxygenation. Ann Hepatol. 2014 Mar-Apr;13(2):256-64. PubMed PMID: 24552868.

3: Mueller BJ, Guessford SA, Chen TT, Karczmarcyk RM, Schreiber MA, Ycas JW, Gorko MA, Repta AJ. Effect of inline filtration on ViaSpan cold-storage solution. Am J Health Syst Pharm. 1998 Feb 1;55(3):266-71. PubMed PMID: 9492257.

4: Trope M, Friedman S. Periodontal healing of replanted dog teeth stored in Viaspan, milk and Hank's balanced salt solution. Endod Dent Traumatol. 1992 Oct;8(5):183-8. PubMed PMID: 1302677.

5: Hiltz J, Trope M. Vitality of human lip fibroblasts in milk, Hanks balanced salt solution and Viaspan storage media. Endod Dent Traumatol. 1991 Apr;7(2):69-72. PubMed PMID: 1782897.

6: Sigvardson KW, Eliason MS, Herbranson DE. Determination of raffinose and lactobionic acid in ViaSpan by anion exchange chromatography with pulsed amperometric detection. J Pharm Biomed Anal. 1996 Nov;15(2):227-31. PubMed PMID: 8933424.

7: Audet M, Alexandre E, Mustun A, David P, Chenard-Neu MP, Tiollier J, Jaeck D, Cinqualbre J, Wolf P, Boudjema K. Comparative evaluation of Celsior solution versus Viaspan in a pig liver transplantation model. Transplantation. 2001 Jun 27;71(12):1731-5. PubMed PMID: 11455250.

8: Tesi RJ, Jaffe BM, McBride V, Haque S. Histopathologic changes in human small intestine during storage in Viaspan organ preservation solution. Arch Pathol Lab Med. 1997 Jul;121(7):714-8. PubMed PMID: 9240907.

9: Trope M, Hupp JG, Mesaros SV. The role of the socket in the periodontal healing of replanted dogs' teeth stored in ViaSpan for extended periods. Endod Dent Traumatol. 1997 Aug;13(4):171-5. PubMed PMID: 9550042.

10: Moukarzel M, Chalouhy C, Kallas Chemaly A. Milestones and Basic Principles. J Med Liban. 2015 Jul-Sep;63(3):126-30. Review. PubMed PMID: 26591191.

11: Pizarro MD, Mediavilla MG, Quintana AB, Scandizzi ÁL, Rodriguez JV, Mamprin ME. Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver. World J Hepatol. 2016 Nov 28;8(33):1442-1451. PubMed PMID: 27957242; PubMed Central PMCID: PMC5124715.

12: Cierpka L, Ryszka F, Dolińska B, Smorąg Z, Słomski R, Wiaderkiewicz R, Caban A, Budziński G, Oczkowicz G, Wieczorek J. Biolasol: novel perfusion and preservation solution for kidneys. Transplant Proc. 2014 Oct;46(8):2539-41. doi: 10.1016/j.transproceed.2014.09.016. PubMed PMID: 25380859.

13: Corwin WL, Baust JM, Vanbuskirk RG, Baust JG. In Vitro Assessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model. Biopreserv Biobank. 2009 Mar;7(1):19-27. PubMed PMID: 22087352; PubMed Central PMCID: PMC3205736.

14: Voigt MR, DeLario GT. Perspectives on abdominal organ preservation solutions: a comparative literature review. Prog Transplant. 2013 Dec;23(4):383-91. doi: 10.7182/pit2013100. Review. PubMed PMID: 24311404.

15: Blankensteijn JD, Terpstra OT. Liver preservation: the past and the future. Hepatology. 1991 Jun;13(6):1235-50. Review. PubMed PMID: 2050338.

16: Collins GM. What solutions are best? Overview of flush solutions. Transplant Proc. 1997 Dec;29(8):3543-4. Review. PubMed PMID: 9414829.

17: Battula NR, Andreoni KA. Oxygenated Preservation Solutions for Organ Preservation. Transplantation. 2019 Feb;103(2):233-234. doi: 10.1097/TP.0000000000002531. PubMed PMID: 30422951.

18: Lakey JR, Tsujimura T, Shapiro AM, Kuroda Y. Preservation of the human pancreas before islet isolation using a two-layer (UW solution-perfluorochemical) cold storage method. Transplantation. 2002 Dec 27;74(12):1809-11. Review. PubMed PMID: 12499905.

19: Hosgood SA, Nicholson ML. The role of perfluorocarbon in organ preservation. Transplantation. 2010 May 27;89(10):1169-75. doi: 10.1097/TP.0b013e3181da6064. PubMed PMID: 20393403.

20: Buttke TM, Trope M. Effect of catalase supplementation in storage media for avulsed teeth. Dent Traumatol. 2003 Apr;19(2):103-8. PubMed PMID: 12656842.