JC1-40

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533306

CAS#: N/A

Description: JC1-40 is a novel RORα activator, diminishing diethylnitrosamine-induced acute liver injury and repressing transcriptional expression of APPs such as CXCL1 and LCN2 in mice.


Chemical Structure

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JC1-40
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 533306
Name: JC1-40
CAS#: N/A
Chemical Formula: C16H18N2OS
Exact Mass: 286.114
Molecular Weight: 286.393
Elemental Analysis: C, 67.10; H, 6.34; N, 9.78; O, 5.59; S, 11.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JC1-40; JC1 40; JC140

IUPAC/Chemical Name: 1-(4-Benzyloxy-benzyl)-3-methyl-thiourea

InChi Key: WTJHYYAEJUIEOB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H18N2OS/c1-17-16(20)18-11-13-7-9-15(10-8-13)19-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H2,17,18,20)

SMILES Code: S=C(NC)NCC1=CC=C(OCC2=CC=CC=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 286.393 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kim JY, Han YH, Nam MW, Kim HJ, Lee MO. RORα suppresses interleukin-6-mediated
hepatic acute phase response. Sci Rep. 2019 Aug 13;9(1):11798. doi:
10.1038/s41598-019-48171-8. PubMed PMID: 31409825; PubMed Central PMCID:
PMC6692401.

2: Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO. RORα Induces
KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against
Nonalcoholic Steatohepatitis. Cell Rep. 2017 Jul 5;20(1):124-135. doi:
10.1016/j.celrep.2017.06.017. PubMed PMID: 28683306.

3: Han YH, Kim DK, Na TY, Ka NL, Choi HS, Lee MO. RORα switches transcriptional
mode of ERRγ that results in transcriptional repression of CYP2E1 under
ethanol-exposure. Nucleic Acids Res. 2016 Feb 18;44(3):1095-104. doi:
10.1093/nar/gkv1034. Epub 2015 Oct 12. PubMed PMID: 26464440; PubMed Central
PMCID: PMC4756810.

4: Han YH, Kim HJ, Kim EJ, Kim KS, Hong S, Park HG, Lee MO. RORα decreases
oxidative stress through the induction of SOD2 and GPx1 expression and thereby
protects against nonalcoholic steatohepatitis in mice. Antioxid Redox Signal.
2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10. PubMed
PMID: 24597775; PubMed Central PMCID: PMC4215383.