WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585349
Description: U 68215 is a prostacyclin analog that inhibits acid secretion without stimulation gastric emptying.
MedKoo Cat#: 585349
Name: U 68215
Chemical Formula: C24H34O5
Exact Mass: 402.2406
Molecular Weight: 402.531
Elemental Analysis: C, 71.61; H, 8.51; O, 19.87
This product is not in stock, which may be available by custom synthesis.
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Synonym: U 68215; U68215; U-68215
IUPAC/Chemical Name: Acetic acid, ((1-(3-cyclohexyl-3-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1H-benz(f)inden-5-yl)oxy)-, (1R-(1alpha(R*),2beta,3aalpha,9aalpha))-
InChi Key: UVTYVOJZXZTZHN-WGMJQOQFSA-N
InChi Code: InChI=1S/C24H34O5/c25-21(15-5-2-1-3-6-15)10-9-18-19-11-16-7-4-8-23(29-14-24(27)28)20(16)12-17(19)13-22(18)26/h4,7-8,15,17-19,21-22,25-26H,1-3,5-6,9-14H2,(H,27,28)/t17-,18+,19-,21?,22+/m1/s1
SMILES Code: O=C(O)COC1=C2C[C@]3([H])C[C@H](O)[C@@H](CCC(C4CCCCC4)O)[C@]3([H])CC2=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 402.531 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shea-Donohue T, Kandasamy A, Dubois A. Effects of a prostacyclin analog, U-68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. J Pharmacol Exp Ther. 1992 Mar;260(3):1023-7. PubMed PMID: 1545375.
2: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68,215. Prostaglandins. 1985 Oct;30(4):619-49. PubMed PMID: 4081062.
3: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Gastrointestinal properties of U-68,215, a stable prostacyclin analogue. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:641-4. PubMed PMID: 2936188.