U 26384

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585344

CAS#: 112646-88-5

Description: U 26384 is a phospholipase A2 inhibitor reduces the severity of cell injury, but does not maintain cell viability in cultured human astroglial cell line UC-11MG during ATP depletion.

Chemical Structure

U 26384
CAS# 112646-88-5

Theoretical Analysis

MedKoo Cat#: 585344
Name: U 26384
CAS#: 112646-88-5
Chemical Formula: C25H42N2O
Exact Mass: 386.3297
Molecular Weight: 386.624
Elemental Analysis: C, 77.67; H, 10.95; N, 7.25; O, 4.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: U 26384; U26384; U-26384

IUPAC/Chemical Name: N'-[(13S,17S)-3-methoxy-13-methyl-1,4,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-N,N,N'-trimethylpropane-1,3-diamine


InChi Code: InChI=1S/C25H42N2O/c1-25-14-13-21-20-10-8-19(28-5)17-18(20)7-9-22(21)23(25)11-12-24(25)27(4)16-6-15-26(2)3/h8,21-24H,6-7,9-17H2,1-5H3/t21?,22?,23?,24-,25-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 386.624 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Atwa MA, Smallridge RC, Burch HB, Gist ID, Lu R, Abo-Hashem EM, el-Kannishy MH, Burman KD. Immunoglobulins from Graves' disease patients stimulate phospholipase A2 and C systems in FRTL-5 and human thyroid cells. Eur J Endocrinol. 1996 Sep;135(3):322-7. PubMed PMID: 8890723.

2: Smallridge RC, Gist ID. P2-purinergic stimulation of iodide efflux in FRTL-5 rat thyroid cells involves parallel activation of PLC and PLA2. Am J Physiol. 1994 Aug;267(2 Pt 1):E323-30. PubMed PMID: 8074212.

3: Sun FF, Fleming WE, Taylor BM. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochem Pharmacol. 1993 Mar 9;45(5):1149-55. PubMed PMID: 8461044.

4: Schnellmann RG, Yang X, Carrick JB. Arachidonic acid release in renal proximal tubule cell injuries and death. J Biochem Toxicol. 1994 Aug;9(4):211-7. PubMed PMID: 7853355.

5: Sen A, Miller JC, Reynolds R, Willerson JT, Buja LM, Chien KR. Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. J Clin Invest. 1988 Oct;82(4):1333-8. PubMed PMID: 3139713; PubMed Central PMCID: PMC442688.

6: Jones RL, Miller JC, Hagler HK, Chien KR, Willerson JT, Buja LM. Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am J Pathol. 1989 Sep;135(3):541-56. PubMed PMID: 2506756; PubMed Central PMCID: PMC1879881.

7: Nicotera P, Rundgren M, Porubek DJ, Cotgreave I, Moldéus P, Orrenius S, Nelson SD. On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes. Chem Res Toxicol. 1989 Jan-Feb;2(1):46-50. PubMed PMID: 2535261.