WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585344
CAS#: 112646-88-5
Description: U 26384 is a phospholipase A2 inhibitor reduces the severity of cell injury, but does not maintain cell viability in cultured human astroglial cell line UC-11MG during ATP depletion.
MedKoo Cat#: 585344
Name: U 26384
CAS#: 112646-88-5
Chemical Formula: C25H42N2O
Exact Mass: 386.3297
Molecular Weight: 386.624
Elemental Analysis: C, 77.67; H, 10.95; N, 7.25; O, 4.14
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Synonym: U 26384; U26384; U-26384
IUPAC/Chemical Name: N'-[(13S,17S)-3-methoxy-13-methyl-1,4,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-N,N,N'-trimethylpropane-1,3-diamine
InChi Key: FPNKVECDQYFDBG-BOSQQAFTSA-N
InChi Code: InChI=1S/C25H42N2O/c1-25-14-13-21-20-10-8-19(28-5)17-18(20)7-9-22(21)23(25)11-12-24(25)27(4)16-6-15-26(2)3/h8,21-24H,6-7,9-17H2,1-5H3/t21?,22?,23?,24-,25-/m0/s1
SMILES Code: CN([C@H]1CCC2C3CCC4=C(CC=C(OC)C4)C3CC[C@]12C)CCCN(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 386.624 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Atwa MA, Smallridge RC, Burch HB, Gist ID, Lu R, Abo-Hashem EM, el-Kannishy MH, Burman KD. Immunoglobulins from Graves' disease patients stimulate phospholipase A2 and C systems in FRTL-5 and human thyroid cells. Eur J Endocrinol. 1996 Sep;135(3):322-7. PubMed PMID: 8890723.
2: Smallridge RC, Gist ID. P2-purinergic stimulation of iodide efflux in FRTL-5 rat thyroid cells involves parallel activation of PLC and PLA2. Am J Physiol. 1994 Aug;267(2 Pt 1):E323-30. PubMed PMID: 8074212.
3: Sun FF, Fleming WE, Taylor BM. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochem Pharmacol. 1993 Mar 9;45(5):1149-55. PubMed PMID: 8461044.
4: Schnellmann RG, Yang X, Carrick JB. Arachidonic acid release in renal proximal tubule cell injuries and death. J Biochem Toxicol. 1994 Aug;9(4):211-7. PubMed PMID: 7853355.
5: Sen A, Miller JC, Reynolds R, Willerson JT, Buja LM, Chien KR. Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. J Clin Invest. 1988 Oct;82(4):1333-8. PubMed PMID: 3139713; PubMed Central PMCID: PMC442688.
6: Jones RL, Miller JC, Hagler HK, Chien KR, Willerson JT, Buja LM. Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am J Pathol. 1989 Sep;135(3):541-56. PubMed PMID: 2506756; PubMed Central PMCID: PMC1879881.
7: Nicotera P, Rundgren M, Porubek DJ, Cotgreave I, Moldéus P, Orrenius S, Nelson SD. On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes. Chem Res Toxicol. 1989 Jan-Feb;2(1):46-50. PubMed PMID: 2535261.
