Danshensu sodium
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MedKoo CAT#: 574142

CAS#: 67920-52-9

Description: Danshensu sodium is a salvianolic acid that reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage. It increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP). Danshensu reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 300 2 Weeks
1g USD 1410 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Danshensu sodium, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 574142
Name: Danshensu sodium
CAS#: 67920-52-9
Chemical Formula: C9H9NaO5
Exact Mass: 220.0348
Molecular Weight: 220.16
Elemental Analysis: C, 49.10; H, 4.12; Na, 10.44; O, 36.34


Synonym: Danshensu sodium

IUPAC/Chemical Name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt

InChi Key: ZMMKVDBZTXUHFO-UHFFFAOYSA-M

InChi Code: InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1

SMILES Code: OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Fan, G., Yu, J., Asare, P.F., et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J. Cell Mol. Med. 20(10), 1908-1919 (2016).

2. Yin, Y., Duan, J., Guo, C., et al. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis. Eur. J. Pharmacol. 814, 274-282 (2017).

3. Cao, H.Y., Ding, R.L., Li, M., et al. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice. Oncol. Lett. 13(2), 605-612 (2017).

4. Xu, H., Liu, W., Liu, T., et al. Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats. Oncotarget 8(70), 115434-115443 (2017).