UH 301

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585325

CAS#: 127126-21-0

Description: UH 301 is a 5-HT1A receptor antagonist.

Chemical Structure

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UH 301
CAS# 127126-21-0
Instruction

Theoretical Analysis

MedKoo Cat#: 585325
Name: UH 301
CAS#: 127126-21-0
Chemical Formula: C16H24FNO
Exact Mass: 265.18
Molecular Weight: 265.372
Elemental Analysis: C, 72.42; H, 9.12; F, 7.16; N, 5.28; O, 6.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UH 301; UH301; UH-301

IUPAC/Chemical Name: 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, (S)-

InChi Key: FNKBVTBXFLSTPB-LBPRGKRZSA-N

InChi Code: InChI=1S/C16H24FNO/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17/h7-8,12,19H,3-6,9-11H2,1-2H3/t12-/m0/s1

SMILES Code: OC1=C2C[C@@H](N(CCC)CCC)CCC2=C(F)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yan H, Yu H, Lewander T. An integrative pharmacokinetic and pharmacodynamic study of the 5-HT1A receptor antagonist (S)-UH-301 in the rat. Eur Neuropsychopharmacol. 2002 Apr;12(2):101-10. PubMed PMID: 11872325.

2: Nomikos GG, Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum. J Neural Transm (Vienna). 1996;103(5):541-54. PubMed PMID: 8811500.

3: Ahlenius S, Henriksson I, Magnusson O, Salmi P. In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):15-9. PubMed PMID: 10082223.

4: Dahlin M, Björk E. Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. Int J Pharm. 2000 Feb 15;195(1-2):197-205. PubMed PMID: 10675697.

5: Darmani NA, Reeves SL. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacol Biochem Behav. 1996 Sep;55(1):1-10. PubMed PMID: 8870031.

6: Moreau JL, Griebel G, Jenck F, Martin JR, Widmer U, Haefely WE. Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys. Brain Res Bull. 1992 Dec;29(6):901-4. PubMed PMID: 1473022.

7: Johansson CE, Meyerson BJ, Hacksell U. The novel 5-HT1A receptor antagonist (S)-UH-301 antagonizes 8-OH-DPAT-induced effects on male as well as female rat copulatory behaviour. Eur J Pharmacol. 1991 Sep 4;202(1):81-7. PubMed PMID: 1838499.

8: Arborelius L, Nomikos GG, Hertel P, Salmi P, Grillner P, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1996 May;353(6):630-40. PubMed PMID: 8738296.

9: Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 blocks the qR)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. J Neural Transm Gen Sect. 1994;96(3):179-86. PubMed PMID: 7826569.

10: Arborelius L, Chergui K, Murase S, Nomikos GG, Höök BB, Chouvet G, Hacksell U, Svensson TH. The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn Schmiedebergs Arch Pharmacol. 1993 Apr;347(4):353-62. PubMed PMID: 8510763.

11: Nomikos GG, Arborelius L, Svensson TH. The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. Eur J Pharmacol. 1992 Jun 17;216(3):373-8. PubMed PMID: 1425929.

12: Björk L, Fredriksson A, Hacksell U, Lewander T. Effects of (R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of (R)-8-OH-DPAT-induced effects. Eur Neuropsychopharmacol. 1992 Jun;2(2):141-7. PubMed PMID: 1385999.

13: Stevens KE, O'Neill HC, Rose GM, Luthman J. The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids. 2006 Nov;31(4):365-75. Epub 2006 Aug 2. PubMed PMID: 16868646.

14: Koprowska M, Krotewicz M, Romaniuk A, Strzelczuk M, Wieczorek M. Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats. Acta Neurobiol Exp (Wars). 2002;62(2):63-74. Erratum in: Acta Neurobiol Exp (Warsz). 2002;62(4):283.. PubMed PMID: 12201034.

15: Björk L, Lindgren S, Hacksell U, Lewander T. (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat. Eur J Pharmacol. 1991 Jul 9;199(3):367-70. PubMed PMID: 1833212.

16: Sylte I, Edvardsen O, Dahl SG. Molecular modelling of UH-301 and 5-HT(1a) receptor interactions. Protein Eng. 1996 Feb;9(2):149-60. PubMed PMID: 9005436.

17: Arborelius L, Nomikos GG, Grillner P, Hertel P, Höök BB, Hacksell U, Svensson TH. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):157-65. PubMed PMID: 7477438.

18: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. PubMed PMID: 19837141.

19: Meneses A, Hong E. 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats. Neurobiol Learn Mem. 1999 Mar;71(2):207-18. PubMed PMID: 10082640.

20: Griebel G, Rodgers RJ, Perrault G, Sanger DJ. Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists. Psychopharmacology (Berl). 1999 May;144(2):121-30. PubMed PMID: 10394992.