CGP52411
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471033

CAS#: 145915-58-8

Description: CGP52411, also known as DAPH, is a selective inhibitor of the epidermal growth factor receptor (EGFR). It is also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. It may offer therapeutic agents for the treatment of hyperproliferative diseases.


Price and Availability

Size
Price

10mg
USD 335
Size
Price

50mg
USD 945
Size
Price

CGP52411, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 471033
Name: CGP52411
CAS#: 145915-58-8
Chemical Formula: C20H15N3O2
Exact Mass: 329.1164
Molecular Weight: 329.36
Elemental Analysis: C, 72.94; H, 4.59; N, 12.76; O, 9.72


Synonym: CGP52411; CGP 52411; CGP-52411; DAPH

IUPAC/Chemical Name: 5,6-bis(phenylamino)isoindoline-1,3-dione

InChi Key: AAALVYBICLMAMA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)

SMILES Code: O=C1NC(C2=CC(NC3=CC=CC=C3)=C(C=C21)NC4=CC=CC=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1. Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256

2. Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848

3. Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396