WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533239
Description: JS-11 is a novel hNPR1 antagonist, inhibiting receptor activity through a noncompetitive mechanism, inhibiting itching in a mouse model of contact dermatitis.
MedKoo Cat#: 533239
Chemical Formula: C23H28N4O3
Exact Mass: 408.2161
Molecular Weight: 408.502
Elemental Analysis: C, 67.63; H, 6.91; N, 13.72; O, 11.75
This product is not in stock, which may be available by custom synthesis.
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Synonym: JS-11; JS 11 JS11
IUPAC/Chemical Name: 1-Cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide
InChi Key: OHSMTKLVCHFYEF-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H28N4O3/c1-15-11-19(30-25-15)13-24-22(28)17-9-10-20-21(12-17)26(14-16-7-8-16)23(29)27(20)18-5-3-2-4-6-18/h9-12,16,18H,2-8,13-14H2,1H3,(H,24,28)
SMILES Code: O=C(C1=CC=C(C(N2CC3CC3)=C1)N(C4CCCCC4)C2=O)NCC5=CC(C)=NO5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 408.502 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|