dTAG-13
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MedKoo CAT#: 465036

CAS#: 2064175-41-1

Description: dTAG-13 is extremely selective for degradation of FKBP12F36V fusion chimeras. IP administration of dTAG-13 (25 mg/kg) significantly diminished bioluminescent signal in a disseminated model of leukemia (MV4;11 cells expressing luciferase-FKBP12F36V) in 4 h (Nabet et al.).


Chemical Structure

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dTAG-13
CAS# 2064175-41-1

Theoretical Analysis

MedKoo Cat#: 465036
Name: dTAG-13
CAS#: 2064175-41-1
Chemical Formula: C57H68N4O15
Exact Mass: 1,048.47
Molecular Weight: 1,049.180
Elemental Analysis: C, 65.25; H, 6.53; N, 5.34; O, 22.87

Price and Availability

Size Price Availability Quantity
1mg USD 450 2 Weeks
5mg USD 1250 2 Weeks
10mg USD 1950 2 Weeks
25mg USD 3650 2 Weeks
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Related CAS #: 2064175-41-1;  

Synonym: dTAG-13; dTAG13; dTAG 13;

IUPAC/Chemical Name: (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-(2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

InChi Key: BJFBRLAWLPZOMJ-VOSOTEEESA-N

InChi Code: InChI=1S/C57H68N4O15/c1-7-37(36-32-47(71-4)52(73-6)48(33-36)72-5)54(65)60-29-14-12-19-41(60)57(68)76-43(25-22-35-23-26-44(69-2)46(31-35)70-3)38-17-10-11-20-42(38)75-34-50(63)58-28-13-8-9-15-30-74-45-21-16-18-39-51(45)56(67)61(55(39)66)40-24-27-49(62)59-53(40)64/h10-11,16-18,20-21,23,26,31-33,37,40-41,43H,7-9,12-15,19,22,24-25,27-30,34H2,1-6H3,(H,58,63)(H,59,62,64)/t37?,40?,41-,43+/m0/s1

SMILES Code: O=C([C@H]1N(C(C(C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)CCC7=CC=C(OC)C(OC)=C7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,049.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Erb et al., Nature 2017 (https://www.nature.com/articles/nature21688) Nabet et al., Nature Chemical Biology 2018 https://www.nature.com/articles/s41589-018-0021-8)

2. https://graylab.dana-farber.org/probes.html