WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465030
Description: JH-XI-05-01 blocks phosphorylation of SR proteins. JX-XI-05-01 is a covalent SRPK1/2 inhibitor that potently converts VEGF from pro-angiogenic to anti-angiogenic isoform.
MedKoo Cat#: 465030
Chemical Formula: C27H21FN2O3S
Exact Mass: 472.1257
Molecular Weight: 472.53
Elemental Analysis: C, 68.63; H, 4.48; F, 4.02; N, 5.93; O, 10.16; S, 6.78
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 2089226-94-6;
Synonym: JH-XI-05-01; JHXI0501; JH XI 05 01;
IUPAC/Chemical Name: 3-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8- yl)benzenesulfonyl fluoride
InChi Key: TWKWEBMGDALHPN-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H21FN2O3S/c1-4-16-12-21-22(13-20(16)17-6-5-7-18(11-17)34(28,32)33)27(2,3)26-24(25(21)31)19-9-8-15(14-29)10-23(19)30-26/h5-13,30H,4H2,1-3H3
SMILES Code: O=S(F)(C1=CC=CC(C2=C(CC)C=C3C(C(C4=C(N5)C=C(C=C4)C#N)=C5C(C)(C3= C2)C)=O)=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 472.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. doi: 10.1016/j.chembiol.2018.01.013. Epub 2018 Feb 22. PubMed PMID: 29478907; PubMed Central PMCID: PMC5973797.