UR 11353

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585302

CAS#: 138060-13-6

Description: UR 11353 is a PAF antagonist that may be useful in treatment of some inflammatory skin diseases.

Chemical Structure

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UR 11353
CAS# 138060-13-6
Instruction

Theoretical Analysis

MedKoo Cat#: 585302
Name: UR 11353
CAS#: 138060-13-6
Chemical Formula: C34H59ClN2O5
Exact Mass: 610.41
Molecular Weight: 611.305
Elemental Analysis: C, 66.80; H, 9.73; Cl, 5.80; N, 4.58; O, 13.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UR 11353; UR11353; UR-11353

IUPAC/Chemical Name: Pyridinium, 2-((acetyl(((tetrahydro5-(octadecyloxy)-3-furanyl)methoxy)carbonyl)amino)methyl)-1-ethyl, chloride

InChi Key: KFNNWINXWGVOQN-UHFFFAOYSA-M

InChi Code: InChI=1S/C34H59N2O5.ClH/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-39-33-26-31(28-40-33)29-41-34(38)36(30(3)37)27-32-23-20-21-24-35(32)5-2;/h20-21,23-24,31,33H,4-19,22,25-29H2,1-3H3;1H/q+1;/p-1

SMILES Code: CC[N+]1=CC=CC=C1CN(C(C)=O)C(OCC2COC(OCCCCCCCCCCCCCCCCCC)C2)=O.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 611.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

2: Merlos M, Gómez LA, Giral M, Vericat ML, García-Rafanell J, Forn J. Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents. Br J Pharmacol. 1991 Dec;104(4):990-4. PubMed PMID: 1810607; PubMed Central PMCID: PMC1908842.

3: Carceller E, Merlos M, Giral M, Bartrolí J, García-Rafanell J, Forn J. 4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists. J Med Chem. 1992 Feb 21;35(4):676-83. PubMed PMID: 1542094.