K811

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MedKoo CAT#: 465016

CAS#: 1355228-38-4

Description: K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers.

Chemical Structure

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K811
CAS# 1355228-38-4
Instruction

Theoretical Analysis

MedKoo Cat#: 465016
Name: K811
CAS#: 1355228-38-4
Chemical Formula: C29H26N4O5
Exact Mass: 510.19
Molecular Weight: 510.550
Elemental Analysis: C, 68.22; H, 5.13; N, 10.97; O, 15.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1355228-38-4; 1355228-39-5  

Synonym: K811; K 811; K811

IUPAC/Chemical Name: N-(4-((6,7-dimethoxycinnolin-4-yl)oxy)phenyl)-1-isopropyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

InChi Key: JVQKIXBAOVAPKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H26N4O5/c1-17(2)33-16-22(28(34)20-7-5-6-8-24(20)33)29(35)31-18-9-11-19(12-10-18)38-27-15-30-32-23-14-26(37-4)25(36-3)13-21(23)27/h5-17H,1-4H3,(H,31,35)

SMILES Code: COC1=CC2=C(C=C1OC)C(OC3=CC=C(NC(C4=CN(C(C)C)C(C=CC=C5)=C5C4=O)=O)C=C3)=CN=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 510.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fujisawa T, Takahashi M, Tsukamoto Y, Yamaguchi N, Nakoji M, Endo M, Kodaira H, Hayashi Y, Nishitoh H, Naguro I, Homma K, Ichijo H. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2016 Jan 15;25(2):245-53. doi: 10.1093/hmg/ddv467. Epub 2015 Nov 24. PubMed PMID: 26604152.

2: Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64. doi: 10.1517/14728222.2014.896903. Epub 2014 Mar 24. Review. PubMed PMID: 24660755.

3: Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K. Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer. Cancer Sci. 2012 Dec;103(12):2181-5. doi: 10.1111/cas.12024. Epub 2012 Oct 30. PubMed PMID: 23110662.

4: Jadhav TS, Wooten MW, Wooten MC. Mining the TRAF6/p62 interactome for a selective ubiquitination motif. BMC Proc. 2011 May 28;5 Suppl 2:S4. doi: 10.1186/1753-6561-5-S2-S4. PubMed PMID: 21554762; PubMed Central PMCID: PMC3090762.

5: Tchesnokov EP, Gilbert C, Boivin G, Götte M. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. J Virol. 2006 Feb;80(3):1440-50. PubMed PMID: 16415021; PubMed Central PMCID: PMC1346920.

6: Martorell L, Zaera MG, Valero J, Serrano D, Figuera L, Joven J, Labad A, Vilella E, Nunes V. The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders. Psychiatr Genet. 2003 Mar;13(1):29-32. PubMed PMID: 12605098.