Dansyl chloride

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MedKoo CAT#: 574121

CAS#: 605-65-2

Description: Dansyl chloride is a reactive probe for the derivatization of primary amines, including those on amino acids, peptides, and polyamines, for detection by HPLC. It has also been used for the derivatization of compounds containing phenol groups, such as steroids, for detection by MS/MS. Dansyl chloride is a fluorescent probe for proteins and enzymes. It displays excitation/emission maxima of 340/535 nm, respectively, in acetone.

Price and Availability

Size Price Shipping out time Quantity
1g USD 210 2 Weeks
5g USD 385 2 Weeks
10g USD 630 2 Weeks
25g USD 975 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Dansyl chloride, purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 574121
Name: Dansyl chloride
CAS#: 605-65-2
Chemical Formula: C12H12ClNO2S
Exact Mass: 269.0277
Molecular Weight: 269.74
Elemental Analysis: C, 53.43; H, 4.48; Cl, 13.14; N, 5.19; O, 11.86; S, 11.89

Synonym: Dansyl chloride, DNS-Cl, NSC 83616

IUPAC/Chemical Name: 5-(dimethylamino)-1-naphthalenesulfonyl chloride


InChi Code: InChI=1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3

SMILES Code: CN(C)C1=CC=CC2=C1C=CC=C2S(Cl)(=O)=O

Technical Data

Solid powder

>95% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Emission: 535 nm, in acetone
Excitation: 340 nm, in acetone


1. Walker, J.M. The dansyl method for identifying N-terminal amino acids. Methods in molecular biology: Basic protein and peptide protocols 32, 321-328 (1994).

2. Takeuchi, T. HPLC of amino acids as dansyl and dabsyl derivatives. J. Chromatogr. Lib. 70, 229-241 (2005).

3. Hunter, K.J. A dansyl chloride-HPLC method for the determination of polyamines. Methods in molecular biology: Polyamine protocols 79, 119-123 (1998).

4. Santa, T. Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry. Biomed. Chromatogr. 25(1-2), 1-10 (2011).

5. Chen, R.F., and Scott, C.H. Atlas of fluorescence spectra and lifetimes of dyes attached to protein. Anal. Lett. 18(4), 393-421 (1985).