WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555693

CAS#: 131359-24-5

Description: 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.

Chemical Structure

CAS# 131359-24-5

Theoretical Analysis

MedKoo Cat#: 555693
Name: 2-HBA
CAS#: 131359-24-5
Chemical Formula: C17H14O3
Exact Mass: 266.0943
Molecular Weight: 266.296
Elemental Analysis: C, 76.68; H, 5.30; O, 18.02

Price and Availability

Size Price Availability Quantity
200.0mg USD 450.0 2 Weeks
500.0mg USD 850.0 2 Weeks
1.0g USD 1550.0 2 Weeks
2.0g USD 2650.0 2 Weeks
5.0g USD 4650.0 2 Weeks
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Synonym: 2-HBA

IUPAC/Chemical Name: (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one


InChi Code: InChI=1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 266.296 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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200.0mg / USD 450.0