2-HBA
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MedKoo CAT#: 555693

CAS#: 131359-24-5

Description: 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.


Price and Availability

Size
Price

100mg
USD 550
1g
USD 2950
Size
Price

200mg
USD 950
2g
USD 4950
Size
Price

500mg
USD 1650
5g
USD 6950

2-HBA, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555693
Name: 2-HBA
CAS#: 131359-24-5
Chemical Formula: C17H14O3
Exact Mass: 266.0943
Molecular Weight: 266.296
Elemental Analysis: C, 76.68; H, 5.30; O, 18.02


Synonym: 2-HBA

IUPAC/Chemical Name: (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one

InChi Key: YNVAHBUBGBLIEY-WGDLNXRISA-N

InChi Code: InChI=1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+

SMILES Code: O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

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