Bemotrizinol
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585271

CAS#: 187393-00-6

Description: Bemotrizinol is a UVA absorber used as a topical sunscreen.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 350 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-15. Prices are subject to change without notice.

Bemotrizinol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 585271
Name: Bemotrizinol
CAS#: 187393-00-6
Chemical Formula: C38H49N3O5
Exact Mass: 627.3672
Molecular Weight: 627.826
Elemental Analysis: C, 72.70; H, 7.87; N, 6.69; O, 12.74


Synonym: Bemotrizinol; Tinosorb S

IUPAC/Chemical Name: Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-

InChi Key: XVAMCHGMPYWHNL-UHFFFAOYSA-N

InChi Code: InChI=1S/C38H49N3O5/c1-6-10-12-26(8-3)24-45-30-18-20-32(34(42)22-30)37-39-36(28-14-16-29(44-5)17-15-28)40-38(41-37)33-21-19-31(23-35(33)43)46-25-27(9-4)13-11-7-2/h14-23,26-27,42-43H,6-13,24-25H2,1-5H3

SMILES Code: COC1=CC=C(C2=NC(C3=CC=C(OCC(CC)CCCC)C=C3O)=NC(C4=CC=C(OCC(CC)CCCC)C=C4O)=N2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA. Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S. Regul Toxicol Pharmacol. 2001 Dec;34(3):287-91. PubMed PMID: 11754532.

2: Benevenuto CG, Guerra LO, Gaspar LR. Combination of retinyl palmitate and UV-filters: phototoxic risk assessment based on photostability and in vitro and in vivo phototoxicity assays. Eur J Pharm Sci. 2015 Feb 20;68:127-36. doi: 10.1016/j.ejps.2014.12.007. Epub 2014 Dec 19. PubMed PMID: 25533240.

3: Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001 Sep;74(3):401-6. PubMed PMID: 11594052.

4: Diffey B. New Sunscreens and the Precautionary Principle. JAMA Dermatol. 2016 May 1;152(5):511-2. doi: 10.1001/jamadermatol.2015.6069. PubMed PMID: 26885870.

5: Dencausse L, Galland A, Clamou JL, Basso J. Validation of HPLC method for quantitative determination of Tinosorb S and three other sunscreens in a high protection cosmetic product. Int J Cosmet Sci. 2008 Oct;30(5):373-82. doi: 10.1111/j.1468-2494.2008.00461.x. PubMed PMID: 18822044.

6: Zgadzaj A, Skrzypczak A, Welenc I, Ługowska A, Parzonko A, Siedlecka E, Sommer S, Sikorska K, Nałęcz-Jawecki G. Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions. J Photochem Photobiol B. 2015 Mar;144:76-84. doi: 10.1016/j.jphotobiol.2015.01.015. Epub 2015 Feb 17. PubMed PMID: 25728226.

7: Souza C, Maia Campos PMBG. Development of a HPLC method for determination of four UV filters in sunscreen and its application to skin penetration studies. Biomed Chromatogr. 2017 Dec;31(12). doi: 10.1002/bmc.4029. Epub 2017 Jul 10. PubMed PMID: 28623841.

8: Peres DD, Ariede MB, Candido TM, de Almeida TS, Lourenço FR, Consiglieri VO, Kaneko TM, Velasco MV, Baby AR. Quality by design (QbD), Process Analytical Technology (PAT), and design of experiment applied to the development of multifunctional sunscreens. Drug Dev Ind Pharm. 2017 Feb;43(2):246-256. doi: 10.1080/03639045.2016.1236809. Epub 2016 Oct 13. PubMed PMID: 27627681.

9: Puglia C, Damiani E, Offerta A, Rizza L, Tirendi GG, Tarico MS, Curreri S, Bonina F, Perrotta RE. Evaluation of nanostructured lipid carriers (NLC) and nanoemulsions as carriers for UV-filters: characterization, in vitro penetration and photostability studies. Eur J Pharm Sci. 2014 Jan 23;51:211-7. doi: 10.1016/j.ejps.2013.09.023. Epub 2013 Oct 21. PubMed PMID: 24157543.

10: Köpke D, Müller RH, Pyo SM. Phenylethyl resorcinol smartLipids for skin brightening - Increased loading & chemical stability. Eur J Pharm Sci. 2019 Sep 1;137:104992. doi: 10.1016/j.ejps.2019.104992. Epub 2019 Jul 11. PubMed PMID: 31302211.

11: Werner MJ. Perspective: protect the USA from UVA. Nature. 2014 Nov 20;515(7527):S126. doi: 10.1038/515S126a. PubMed PMID: 25407712.

12: Young AR, Greenaway J, Harrison GI, Lawrence KP, Sarkany R, Douki T, Boyer F, Josse G, Questel E, Monteil C, Rossi AB. Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo. Acta Derm Venereol. 2018 Oct 10;98(9):880-887. doi: 10.2340/00015555-2992. PubMed PMID: 29944164.

13: Peres DD, Sarruf FD, de Oliveira CA, Velasco MVR, Baby AR. Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF. J Photochem Photobiol B. 2018 Aug;185:46-49. doi: 10.1016/j.jphotobiol.2018.05.026. Epub 2018 May 26. PubMed PMID: 29864725.

14: Hüglin D. Advanced UV Absorbers for the Protection of Human Skin. Chimia (Aarau). 2016;70(7-8):496-501. doi: 10.2533/chimia.2016.496. Review. PubMed PMID: 27561611.

15: Freitas JV, Lopes NP, Gaspar LR. Photostability evaluation of five UV-filters, trans-resveratrol and beta-carotene in sunscreens. Eur J Pharm Sci. 2015 Oct 12;78:79-89. doi: 10.1016/j.ejps.2015.07.004. Epub 2015 Jul 6. PubMed PMID: 26159738.

16: Shaw T, Simpson B, Wilson B, Oostman H, Rainey D, Storrs F. True photoallergy to sunscreens is rare despite popular belief. Dermatitis. 2010 Jul-Aug;21(4):185-98. PubMed PMID: 20646669.

17: Dueva-Koganov OV, Rocafort C, Orofino S, Osterwalder U, Brito J. Addressing technical challenges associated with the FDA's proposed rules for the UVA in vitro testing procedure. J Cosmet Sci. 2009 Nov-Dec;60(6):587-98. PubMed PMID: 20038348.

18: Freitas JV, Gaspar LR. In vitro photosafety and efficacy screening of apigenin, chrysin and beta-carotene for UVA and VIS protection. Eur J Pharm Sci. 2016 Jun 30;89:146-53. doi: 10.1016/j.ejps.2016.04.032. Epub 2016 Apr 26. PubMed PMID: 27130544.

19: Souza C, Campos PMBGM. Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage. Eur J Pharm Sci. 2017 Jun 15;104:52-64. doi: 10.1016/j.ejps.2017.03.026. Epub 2017 Mar 22. PubMed PMID: 28341613.

20: Jansen R, Osterwalder U, Wang SQ, Burnett M, Lim HW. Photoprotection: part II. Sunscreen: development, efficacy, and controversies. J Am Acad Dermatol. 2013 Dec;69(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2013.08.022. PubMed PMID: 24238180.