WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585269
CAS#: 62499-27-8
Description: Gastrodin is a phenolic glycoside that can penetrate through the blood-brain barrier and has been suggested to have neuroprotective effects against hypoxia.
MedKoo Cat#: 585269
Name: Gastrodin
CAS#: 62499-27-8
Chemical Formula: C13H18O7
Exact Mass: 286.1053
Molecular Weight: 286.28
Elemental Analysis: C, 54.54; H, 6.34; O, 39.12
Synonym: Gastrodin
IUPAC/Chemical Name: 4-(hydroxymethyl)phenyl β-D-glucopyranoside
InChi Key: PUQSUZTXKPLAPR-UJPOAAIJSA-N
InChi Code: InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
SMILES Code: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. |
| In vitro activity: | Treatment with gastrodin attenuated H2O2-induced ferroptosis and decreased lipid reactive oxygen species (ROS) (C11-BODIPY) production in C6 cells. Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. Reference: Biol Pharm Bull. 2020;43(3):480-487. https://pubmed.ncbi.nlm.nih.gov/32115506/ |
| In vivo activity: | Intraperitoneal injection with gastrodin 10 mg/kg or 50 mg/kg once daily for 15d significantly inhibited the loss of RGCs because of AOH damage (Figure 1D, 1E). Compared to the NS group, the density of the RGCs increased to 937.4±141.7 cells/mm2 and 1031±179.2 cells/mm2 , respectively (Figure 1F). These results indicated that systemic gastrodin had a neuroprotective effect on RGCs in the AOH animal model. Reference: Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. https://pubmed.ncbi.nlm.nih.gov/29062764/ |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 104.79 | |
| DMSO | 60.0 | 209.59 | |
| PBS (pH 7.2) | 5.0 | 17.47 | |
| Water | 100.0 | 349.31 |
The following data is based on the product molecular weight 286.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Li S, Yang Q, Zhou Z, Yang X, Liu Y, Hao K, Fu M. Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway. Bioengineered. 2022 May;13(5):12625-12636. doi: 10.1080/21655979.2022.2076499. PMID: 35609324; PMCID: PMC9275977. 2. Jiang T, Chu J, Chen H, Cheng H, Su J, Wang X, Cao Y, Tian S, Li Q. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487. doi: 10.1248/bpb.b19-00824. PMID: 32115506. 3. Fasina OB, Wang J, Mo J, Osada H, Ohno H, Pan W, Xiang L, Qi J. Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation. Front Pharmacol. 2022 Jun 2;13:814271. doi: 10.3389/fphar.2022.814271. PMID: 35721206; PMCID: PMC9201506. 4. Wang JW, Liu YM, Zhao XF, Zhang H. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. doi: 10.18240/ijo.2017.10.01. PMID: 29062764; PMCID: PMC5638966. |
| In vitro protocol: | 1. Li S, Yang Q, Zhou Z, Yang X, Liu Y, Hao K, Fu M. Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway. Bioengineered. 2022 May;13(5):12625-12636. doi: 10.1080/21655979.2022.2076499. PMID: 35609324; PMCID: PMC9275977. 2. Jiang T, Chu J, Chen H, Cheng H, Su J, Wang X, Cao Y, Tian S, Li Q. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487. doi: 10.1248/bpb.b19-00824. PMID: 32115506. |
| In vivo protocol: | 1. Fasina OB, Wang J, Mo J, Osada H, Ohno H, Pan W, Xiang L, Qi J. Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation. Front Pharmacol. 2022 Jun 2;13:814271. doi: 10.3389/fphar.2022.814271. PMID: 35721206; PMCID: PMC9201506. 2. Wang JW, Liu YM, Zhao XF, Zhang H. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. doi: 10.18240/ijo.2017.10.01. PMID: 29062764; PMCID: PMC5638966. |
1. Liu, Y., Gao, J., Peng, M., et al. A review on central nervous system effects of gastrodin. Front. Pharmacol. 9:24, (2018).
2. Wang, X., Tao, J., Qiao, Y., et al. Gastrodin rescues autistic-like phenotypes in valproic acid-induced animal model. Front. Neurol. 9:1052, (2018).
3. Liu, S., Zhou, L., Yang, L., et al. Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. Oncotarget 9(14), 11528-11540 (2018).
4. Zhang, Y., Wang, C., Yu, B., et al. Gastrodin protects against ethanol-induced liver injury and apoptosis in HepG2 cells and animal models of alcoholic liver disease. Biol. Pharm. Bull. 41(5), 670-679 (2018).
