ICAAc
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574090

CAS#: NONE

Description: ICAAc is a solvatochromic fluorescent pH probe. As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications.

Chemical Structure

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ICAAc
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 574090
Name: ICAAc
CAS#: NONE
Chemical Formula: C14H9N3
Exact Mass: 219.08
Molecular Weight: 219.250
Elemental Analysis: C, 76.70; H, 4.14; N, 19.17

Price and Availability

Size Price Availability Quantity
5mg USD 275 2 Weeks
10mg USD 500 2 Weeks
25mg USD 850 2 Weeks
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Synonym: 3-amino-6-Isocyanoacridine, ICAAc

IUPAC/Chemical Name: 6-isocyanoacridin-3-amine

InChi Key: GXXTUSOSNDNJFZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H9N3/c1-16-12-5-3-10-6-9-2-4-11(15)7-13(9)17-14(10)8-12/h2-8H,15H2

SMILES Code: NC1=CC2=C(C=C1)C=C3C(C=C(C=C3)[N+]#[C-])=N2

Appearance: A crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, water, dioxane, and hexane

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO, water, dioxane, or hexane

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Emission: abs/em = 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous buffer Excitation: 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 219.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).