Panaxatriol
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MedKoo CAT#: 574082

CAS#: 32791-84-7

Description: Panaxatriol is a sapogenin that has antiproliferative, cardioprotective, and antidiabetic properties. It inhibits the proliferation of DU15 prostate cancer cells and induces apoptosis by increasing production of reactive oxygen species (ROS) and decreasing the mitochondrial membrane potential. Panaxatriol reduces ischemia and reperfusion-induced myocardial dysfunction, increases left ventricular developed pressure (LVDevP) and glutathione (GSH) levels, and decreases cardiac lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) levels in rats when administered for seven consecutive days prior to injury. Dietary administration of panaxatriol (0.2% for 6 weeks) decreases fasting blood glucose levels in KKAy insulin-resistant mice.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 230 2 Weeks
50mg USD 375 2 Weeks
100mg USD 575 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Panaxatriol, purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 574082
Name: Panaxatriol
CAS#: 32791-84-7
Chemical Formula: C30H52O4
Exact Mass: 476.3866
Molecular Weight: 476.74
Elemental Analysis: C, 75.58; H, 10.99; O, 13.42


Synonym: NSC 308880, Panaxatriol

IUPAC/Chemical Name: (3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-((R)-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

InChi Key: QFJUYMMIBFBOJY-UXZRXANASA-N

InChi Code: InChI=1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1

SMILES Code: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])C[C@@H](O)[C@@]4([H])[C@@]3(C)CC[C@]4([H])[C@]5(C)OC(C)(C)CCC5


Technical Data

Appearance:
Solid powder

Purity:
>95% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Yu, R., Zhang, Y., Xu, Z., et al. Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest. J. BUON. 23(1), 200-204 (2018).

2. Kim, T.-H., and Lee, S.-M. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem. Toxicol. 48(6), 1516-1520 (2010).

3. Takamura, Y., Nomura, M., Uchiyama, A., et al. Effects of aerobic exercise combined with panaxatriol derived from ginseng on insulin resistance and skeletal muscle mass in type 2 diabetic mice. J. Nutr. Sci. Vitaminol. (Tokyo) 63(5), 339-348 (2017).