WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574069
CAS#: NONE
Description: J-2156 is a high affinity human somatostatin receptor 4 (sst4) agonist that reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation. J-2156 also exhibits anxiolytic effects.
MedKoo Cat#: 574069
Name: J-2156
CAS#: NONE
Chemical Formula: C26H29F3N4O6S
Exact Mass: 582.176
Molecular Weight: 582.59
Elemental Analysis: C, 53.60; H, 5.02; F, 9.78; N, 9.62; O, 16.48; S, 5.50
J-2156, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: J-2156, J2156, J 2156
IUPAC/Chemical Name: (1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate
InChi Key: OCEMIQKESMKGAP-GUTACTQSSA-N
InChi Code: InChI=1S/C24H28N4O4S.C2HF3O2/c1-16-11-12-22(19-10-6-5-9-18(16)19)33(31,32)28-20(13-14-25)24(30)27-21(23(26)29)15-17-7-3-2-4-8-17;3-2(4,5)1(6)7/h2-12,20-21,28H,13-15,25H2,1H3,(H2,26,29)(H,27,30);(H,6,7)/t20-,21-;/m0./s1
SMILES Code: O=C(N[C@H](C(N)=O)CC1=CC=CC=C1)[C@@H](NS(=O)(C2=C3C=CC=CC3=C(C)C=C2)=O)CCN.O=C(O)C(F)(F)F
The following data is based on the product molecular weight 582.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Engström et al (2005) Superagonism at the human somatostatin receptor subtype 4. J.Pharmacol.Exp.Ther. 312 332 PMID: 15333679
Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545
Scheich et al (2016) Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Neuropharmacology. 101 204 PMID: 26387439