5,7-Dihydroxychromone
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574052

CAS#: 31721-94-5

Description: 5,7-Dihydroxychromone is a flavone decomposition product with antimicrobial, antioxidant, and neuroprotective properties. It reduces radial growth of the soil pathogenic fungi R. solani and S. rolfsii but has no effect on soil pathogenic bacteria of the genus Bradyrhizobium. 5,7-Dihydroxychromone reduces increases in apoptosis and the levels of reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y neuroblastoma cells. It also increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells.

Chemical Structure

img
5,7-Dihydroxychromone
CAS# 31721-94-5
Instruction

Theoretical Analysis

MedKoo Cat#: 574052
Name: 5,7-Dihydroxychromone
CAS#: 31721-94-5
Chemical Formula: C9H6O4
Exact Mass: 178.03
Molecular Weight: 178.140
Elemental Analysis: C, 60.68; H, 3.40; O, 35.92

Price and Availability

Size Price Availability Quantity
1mg USD 215
5mg USD 390
10mg USD 625
Bulk inquiry

Synonym: 5,7-Dihydroxychromone

IUPAC/Chemical Name: 5,7-dihydroxy-4H-1-benzopyran-4-one

InChi Key: NYCXYKOXLNBYID-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H6O4/c10-5-3-7(12)9-6(11)1-2-13-8(9)4-5/h1-4,10,12H

SMILES Code: OC1=C(C(C=CO2)=O)C2=CC(O)=C1

Appearance: A crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 178.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Vaughn, S.F. Phytotoxic and antimicrobial activity of 5,7-dihydroxychromone from peanut shells. J. Chem. Ecol. 21(2), 107-115 (1995).

2. Kim, D.-W., Lee, K.-t., Kwon, J., et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 130, 25-30 (2015).