WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574052
Description: 5,7-Dihydroxychromone is a flavone decomposition product with antimicrobial, antioxidant, and neuroprotective properties. It reduces radial growth of the soil pathogenic fungi R. solani and S. rolfsii but has no effect on soil pathogenic bacteria of the genus Bradyrhizobium. 5,7-Dihydroxychromone reduces increases in apoptosis and the levels of reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y neuroblastoma cells. It also increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells.
MedKoo Cat#: 574052
Chemical Formula: C9H6O4
Exact Mass: 178.0266
Molecular Weight: 178.14
Elemental Analysis: C, 60.68; H, 3.40; O, 35.92
IUPAC/Chemical Name: 5,7-dihydroxy-4H-1-benzopyran-4-one
InChi Key: NYCXYKOXLNBYID-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H6O4/c10-5-3-7(12)9-6(11)1-2-13-8(9)4-5/h1-4,10,12H
SMILES Code: OC1=C(C(C=CO2)=O)C2=CC(O)=C1
Appearance: A crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 178.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Vaughn, S.F. Phytotoxic and antimicrobial activity of 5,7-dihydroxychromone from peanut shells. J. Chem. Ecol. 21(2), 107-115 (1995).
2. Kim, D.-W., Lee, K.-t., Kwon, J., et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 130, 25-30 (2015).