WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533077
CAS#: N/A
Description: J014 is a Novel cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 100 nM and 60.0 nM for h-cGAS and m-cGAS, respectively).
MedKoo Cat#: 533077
Name: J014
CAS#: N/A
Chemical Formula: C15H11N5O3
Exact Mass: 309.0862
Molecular Weight: 309.285
Elemental Analysis: C, 58.25; H, 3.59; N, 22.64; O, 15.52
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: J014; J-014; J 014
IUPAC/Chemical Name: 4-Nitro-N-(4-phenylpyridin-2-yl)-1H-pyrazole-5-carboxamide
InChi Key: OTSHTQSPIKHBMM-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11N5O3/c21-15(14-12(20(22)23)9-17-19-14)18-13-8-11(6-7-16-13)10-4-2-1-3-5-10/h1-9H,(H,17,19)(H,16,18,21)
SMILES Code: O=C(C1=C([N+]([O-])=O)C=NN1)NC2=NC=CC(C3=CC=CC=C3)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 309.285 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
