WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574038
CAS#: 66163-76-6
Description: 3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite with antioxidant, antiproliferative, antibacterial, and antiviral properties. 2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria. It also inhibits HIV-1 integrase in both coupled and strand transfer assays.
MedKoo Cat#: 574038
Name: 3-Hydroxyterphenyllin
CAS#: 66163-76-6
Chemical Formula: C20H18O6
Exact Mass: 354.1103
Molecular Weight: 354.36
Elemental Analysis: C, 67.79; H, 5.12; O, 27.09
Synonym: 3-Hydroxyterphenyllin
IUPAC/Chemical Name: 3',6'-dimethoxy-[1,1':4',1''-terphenyl]-2',3,4,4''-tetrol
InChi Key: YLSPFNUVVOKJDF-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H18O6/c1-25-17-10-14(11-3-6-13(21)7-4-11)20(26-2)19(24)18(17)12-5-8-15(22)16(23)9-12/h3-10,21-24H,1-2H3
SMILES Code: OC1=CC=C(C2=CC(OC)=C(C3=CC(O)=C(O)C=C3)C(O)=C2OC)C=C1
Appearance: Solid powder
Purity: >70% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 354.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).
2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).
3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).
4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).
