BAY-899

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MedKoo CAT#: 555687

CAS#: Unknown

Description: BAY-899 is a Potent and Selective Antagonist of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

BAY-899 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555687
Name: BAY-899
CAS#: Unknown
Chemical Formula: C25H19F2N5O2
Exact Mass: 459.1507
Molecular Weight: 459.4568
Elemental Analysis: C, 65.35; H, 4.17; F, 8.27; N, 15.24; O, 6.96


Synonym: BAY-899 ; BAY899; BAY 899;

IUPAC/Chemical Name: (5S)-N-[2-(4-Fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide

InChi Key: VKQBTIMLSDGNLG-QHCPKHFHSA-N

InChi Code: InChI=1S/C25H19F2N5O2/c26-17-5-3-16(4-6-17)23-21-2-1-12-28-22(21)11-13-32(23)25(33)31-19-14-29-24(30-15-19)34-20-9-7-18(27)8-10-20/h1-10,12,14-15,23H,11,13H2,(H,31,33)/t23-/m0/s1

SMILES Code: O=C(N1[C@@H](C2=CC=C(F)C=C2)C3=C(N=CC=C3)CC1)NC4=CN=C(OC5=CC=C(F)C=C5)N=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo
Lars WortmannBernhard LindenthalPeter MuhnAlexander WalterReinhard NubbemeyerDieter HeldmannLothar SobekFederica MorandiAnna K. SchreyDieter MoosmayerJudith GüntherJoachim KuhnkeMarcus KoppitzUlrich LueckingUlrike RoehnMartina SchäferKatrin Nowak-ReppelRonald KuehneHilmar WeinmannGernot Langer
Journal of Medicinal Chemistry, Just AcceptedSubscribed Access
Publication Date (Web):October 31, 2019
DOI: 10.1021/acs.jmedchem.9b01382