WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555686

CAS#: Unknown

Description: BAY-298 is a Potent and Selective Antagonist of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. BAY-298 is the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo.

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 555686
Name: BAY-298
CAS#: Unknown
Chemical Formula: C27H21ClFN3O2
Exact Mass: 473.1306
Molecular Weight: 473.9324
Elemental Analysis: C, 68.43; H, 4.47; Cl, 7.48; F, 4.01; N, 8.87; O, 6.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BAY-298; BAY 298; BAY298;

IUPAC/Chemical Name: (5S)-5-(4-Chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide


InChi Code: InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1

SMILES Code: O=C(N1[C@@H](C2=CC=C(Cl)C=C2)C3=C(N=CC=C3)CC1)NC4=CC=C(OC5=CC=C(F)C=C5)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 473.9324 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo
Lars WortmannBernhard LindenthalPeter MuhnAlexander WalterReinhard NubbemeyerDieter HeldmannLothar SobekFederica MorandiAnna K. SchreyDieter MoosmayerJudith GüntherJoachim KuhnkeMarcus KoppitzUlrich LueckingUlrike RoehnMartina SchäferKatrin Nowak-ReppelRonald KuehneHilmar WeinmannGernot Langer
Journal of Medicinal Chemistry, Just AcceptedSubscribed Access
Publication Date (Web):October 31, 2019
DOI: 10.1021/acs.jmedchem.9b01382

Additional Information