WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555685

CAS#: 2304549-73-1

Description: GFB-8438 is a potent TRPC5 inhibitor (IC50 = 150 nM). The inhibition of TRPC5 may provide a novel, effective, and safe approach for the treatment of FSGS and related proteinuric kidney diseases.

Chemical Structure

CAS# 2304549-73-1

Theoretical Analysis

MedKoo Cat#: 555685
Name: GFB-8438
CAS#: 2304549-73-1
Chemical Formula: C16H14ClF3N4O2
Exact Mass: 386.08
Molecular Weight: 386.759
Elemental Analysis: C, 49.69; H, 3.65; Cl, 9.17; F, 14.74; N, 14.49; O, 8.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: GFB-8438; GFB 8438; GFB8438;

IUPAC/Chemical Name: 4-chloro-5-(3-oxo-4-(2-(trifluoromethyl)benzyl)piperazin-1-yl)pyridazin-3(2H)-one


InChi Code: InChI=1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.759200000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model Maolin Yu*Mark W. Ledeboer*Matthew DanielsGoran MalojcicThomas T. TibbittsMarie Coeffet-Le GalXin-Ru Pan-ZhouAmy Westerling-BuiMaria BeconiJohn F. ReillyPeter MundelJean-Christophe Harmange ACS Medicinal Chemistry Letters, Articles ASAP (As Soon As Publishable)Subscribed Access Publication Date (Web):October 22, 2019