SGC2085 free base
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MedKoo CAT#: 408044

CAS#: 1821908-48-8 (free base)

Description: SGC2085 is a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.


Price and Availability

Size
Price

50mg
USD 250
500mg
USD 1650
5g
USD 5850
Size
Price

100mg
USD 450
1g
USD 2450
Size
Price

200mg
USD 850
2g
USD 3850

SGC2085 free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 408044
Name: SGC2085 free base
CAS#: 1821908-48-8 (free base)
Chemical Formula: C19H24N2O2
Exact Mass: 312.1838
Molecular Weight: 312.413
Elemental Analysis: C, 73.05; H, 7.74; N, 8.97; O, 10.24


Related CAS #: 1821908-49-9 (HCl)   1821908-48-8 (free base)    

Synonym: SGC2085 free base; SGC2085; SGC-2085; SGC 2085;

IUPAC/Chemical Name: (S)-2-amino-N-(4-(3,5-dimethylphenoxy)-3-methylbenzyl)propanamide

InChi Key: GLFOFXKMALJTCZ-HNNXBMFYSA-N

InChi Code: InChI=1S/C19H24N2O2/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20/h5-10,15H,11,20H2,1-4H3,(H,21,22)/t15-/m0/s1

SMILES Code: C[C@H](N)C(NCC1=CC=C(OC2=CC(C)=CC(C)=C2)C(C)=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ,
Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery
of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1
(CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47.
doi: 10.1021/acs.jmedchem.6b00668. Epub 2016 Jul 8. Erratum in: J Med Chem. 2016
Aug 25;59(16):7698. PubMed PMID: 27390919.