TP-238 HCl
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MedKoo CAT#: 574026

CAS#: 2415263-05-5 (HCl)

Description: TP-238 HCl is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). TP-238 binds to CECR2 and BPTF with KD values of 10 and 120 nM, respectively, in an isothermal titration calorimetry (ITC) assay and IC50 values of 30 and 350 nM, respectively, in an AlphaScreen® assay.

Chemical Structure

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TP-238 HCl
CAS# 2415263-05-5 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 574026
Name: TP-238 HCl
CAS#: 2415263-05-5 (HCl)
Chemical Formula: C22H31ClN6O3S
Exact Mass: 494.19
Molecular Weight: 495.040
Elemental Analysis: C, 53.38; H, 6.31; Cl, 7.16; N, 16.98; O, 9.70; S, 6.48

Price and Availability

Size Price Availability Quantity
1mg USD 260
5mg USD 520
10mg USD 870
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Related CAS #: 2415263-04-4 (free base)   2415263-05-5 (HCl)    

Synonym: TP-238 HCl, TP-238 hydrochloride; TP-238; TP 238; TP238;

IUPAC/Chemical Name: N-(3-(1H-pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine, hydrochloride

InChi Key: FHVADRKEPFRFFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N6O3S.ClH/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28;/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26);1H

SMILES Code: CN(C)CCCOC1=CC=C(C2=NC(S(C)(=O)=O)=NC(NCCCN3N=CC=C3)=C2)C=C1.Cl

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 495.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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